Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.50 |
| ▸ | NNMT | P40261 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14026652 | 0.88 | NNMT (0.50) | OPRM1OPRK1OPRD1NNMTSLC6A2 | |
| SCHEMBL2987688 | 0.88 | OPRM1 (0.47) | OPRM1OPRK1OPRD1NNMTSLC6A2 | |
| SCHEMBL2997226 | 0.86 | OPRM1 (0.48) | OPRM1OPRK1OPRD1NNMTSLC6A2 | |
| SCHEMBL14026648 | 0.86 | OPRM1 (0.48) | OPRM1OPRK1OPRD1NNMTSLC6A2 | |
| SCHEMBL2994101 | 0.86 | OPRM1 (0.67) | OPRM1OPRK1OPRD1SLC6A2SLC6A3 | |
| SCHEMBL2989341 | 0.84 | OPRM1 (0.48) | OPRM1OPRK1OPRD1NNMTSLC6A2 | |
| SCHEMBL2993233 | 0.84 | OPRM1 (0.48) | OPRM1OPRK1OPRD1NNMTSLC6A2 | |
| SCHEMBL2989757 | 0.84 | OPRM1 (0.48) | OPRM1OPRK1OPRD1NNMTSLC6A2 | |
| SCHEMBL14026657 | 0.84 | OPRM1 (0.48) | OPRM1OPRK1OPRD1NNMTSLC6A2 | |
| SCHEMBL2989794 | 0.84 | OPRM1 (0.51) | OPRM1OPRK1OPRD1NNMTSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173886-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-07-08 | — | — | US | disclosed |
| WO-2008142454-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173886-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | OPRM1, OPRK1, OPRD1 | OPRM1 1/4885OPRK1 2/4885OPRD1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.