Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.48 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114003 | 0.85 | ADORA2B (0.44) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL14618922 | 0.85 | ADORA2B (0.44) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL13247867 | 0.84 | ADORA2B (0.42) | ADORA2AADORA2BADORA1 | |
| SCHEMBL3118882 | 0.83 | PDGFRA (0.46) | ADORA2AADORA2BADORA1 | |
| SCHEMBL13247878 | 0.79 | ADORA2B (0.57) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL3119443 | 0.77 | SIRT1 (0.54) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL4551803 | 0.77 | ADORA2A (0.91) | ADORA2AALDH1A1ADORA2BADORA1ADCY5 | |
| SCHEMBL3235022 | 0.77 | ADORA2B (0.49) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL3118540 | 0.76 | ADORA2B (0.49) | ADORA2AADORA2BADORA1 | |
| SCHEMBL13247661 | 0.76 | ADORA2B (0.49) | ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | XDH, GPR84, GPR88 | ADORA2A 17/4885ALDH1A1 600/4885ADORA2B 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.