Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 5/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | FES | P07332 | 2/20 | 0.36 |
| ▸ | LYN | P07948 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.36 |
| ▸ | FER | P16591 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | MARK3 | P27448 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13249785 | 0.87 | CYP2D6 (0.43) | TSHRP2RX7MTHFD2CCR5LMNA | |
| SCHEMBL13249856 | 0.87 | PTGDR2 (0.38) | P2RX7MTHFD2CCR5KMT2ALMNA | |
| SCHEMBL13249920 | 0.87 | ROCK2 (0.37) | RETAURKAAURKBALKKDM4E | |
| SCHEMBL13249829 | 0.85 | KMT2A (0.44) | ALDH1A1TSHRP2RX7CCR5KMT2A | |
| SCHEMBL13249922 | 0.85 | KMT2A (0.41) | RETKDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL13249868 | 0.84 | HPGD (0.44) | CHRM1KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL13249891 | 0.84 | CYP3A4 (0.46) | ALDH1A1TSHRMAPK1CCR5KMT2A | |
| SCHEMBL13249786 | 0.84 | TSHR (0.45) | KDM4EALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL13249831 | 0.83 | MTHFD2 (0.46) | P2RX7MTHFD2 | |
| SCHEMBL13249795 | 0.83 | MGLL (0.47) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190687-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-07-29 | — | — | US | disclosed |
| US-20100190687-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190687-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, GCGR, GPR65 | RAB9A 1236/4885RET 785/4885AURKA 4444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.