Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95038 | 0.85 | MAPT (0.55) | MAPTL3MBTL1KDM4EGAAHDAC1 | |
| SCHEMBL7164883 | 0.79 | BACE1 (0.56) | MAPTL3MBTL1KDM4EGAAHDAC1 | |
| SCHEMBL10353242 | 0.77 | ACLY (0.48) | MAPTL3MBTL1KDM4EGAAHDAC1 | |
| SCHEMBL132598 | 0.76 | MAPT (0.77) | MAPTL3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL95028 | 0.76 | HDAC1 (0.46) | MAPTL3MBTL1KDM4EGAAHDAC1 | |
| SCHEMBL28119290 | 0.74 | APP (0.52) | MAPTHDAC1BACE1APPMEN1 | |
| SCHEMBL10507600 | 0.74 | SSTR3 (0.51) | MAPTL3MBTL1KDM4EGAAALDH1A1 | |
| SCHEMBL396451 | 0.74 | BACE1 (0.65) | MAPTKDM4EGAAHDAC1BACE1 | |
| SCHEMBL29922357 | 0.74 | BACE1 (0.65) | MAPTKDM4EGAAHDAC1BACE1 | |
| SCHEMBL12263035 | 0.72 | MAPT (0.64) | MAPTL3MBTL1KDM4EGAAAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058085-A1 | Deuterium Modified Benzimidazoles | CONCERT PHARMACEUTICALS, INC. | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058085-A1 | Deuterium Modified Benzimidazoles | POLRMT, EIF2AK2, DUT | MAPT 4232/4885L3MBTL1 2089/4885KDM4E 537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.