Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12662934 | 0.85 | KDM4E (0.49) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL17477885 | 0.83 | KDM4E (0.50) | KDM4EL3MBTL1ALDH1A1HRH3SMN1; SMN2 | |
| SCHEMBL27594360 | 0.80 | KDM4E (0.47) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL3925520 | 0.78 | KDM4E (0.45) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4670524 | 0.76 | KDM4E (0.44) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL14022008 | 0.75 | KDM4E (0.58) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4889842 | 0.75 | ALDH1A1 (0.43) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL23222239 | 0.74 | UBE2T (0.55) | KDM4EALDH1A1SMN1; SMN2TDP1MEN1 | |
| SCHEMBL5363741 | 0.72 | KDM4E (0.55) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL2273392 | 0.72 | KDM4E (0.55) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | KDM4E 2671/4885L3MBTL1 2487/4885ALDH1A1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.