Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.52 |
| ▸ | HRH1 | P35367 | 6/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16085840 | 0.89 | TSHR (0.50) | TSHRHSD17B10ADRA1AHRH1ADRA1B | |
| SCHEMBL14979185 | 0.88 | PTGDR2 (0.51) | TSHRPTGDR2AKR1B1 | |
| SCHEMBL13464823 | 0.85 | KDM4E (0.56) | TSHRADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL13464824 | 0.83 | ADRA1A (0.50) | TSHRHSD17B10ADRA1AHRH1ADRA1B | |
| SCHEMBL3354746 | 0.77 | HSD17B10 (0.61) | TSHRHSD17B10CMA1AKR1B1LMNA | |
| SCHEMBL16153722 | 0.77 | PTGDR2 (0.51) | TSHRPTGDR2 | |
| SCHEMBL14979209 | 0.77 | PTGDR2 (0.50) | TSHRPTGDR2ALOX15 | |
| SCHEMBL6451102 | 0.76 | HSD17B10 (0.60) | TSHRHSD17B10CMA1AKR1B1LMNA | |
| SCHEMBL18860784 | 0.76 | KMT2A (0.54) | TSHRADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL16085847 | 0.75 | CYP1A2 (0.53) | TSHRADRA1AHRH1ADRA1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697203-B1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2017-05-24 | — | — | EP | claimed |
| US-9487506-B2 | Mineralocorticoid receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-08 | — | — | US | claimed |
| US-20140336224-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2014-11-13 | — | — | US | claimed |
| EP-2697203-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corporation (US) | 2014-02-19 | — | — | EP | claimed |
| WO-2012139495-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-10-18 | — | — | WO | claimed |
| EP-2697203-B1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2017-05-24 | — | — | EP | disclosed |
| US-9487506-B2 | Mineralocorticoid receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20140336224-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2014-11-13 | — | — | US | disclosed |
| EP-2697203-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corporation (US) | 2014-02-19 | — | — | EP | disclosed |
| WO-2012139495-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336224-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | NR3C2, MC2R, CYP21A2 | TSHR 222/4885HSD17B10 215/4885ADRA1A 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.