Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10028356 | 0.75 | MAPT (0.40) | SMN1; SMN2MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8906464 | 0.75 | PIN1 (0.39) | MEN1KMT2AGAAL3MBTL1HTT | |
| SCHEMBL28265249 | 0.72 | PIN1 (0.37) | MEN1KMT2AGAAL3MBTL1HTT | |
| SCHEMBL27508846 | 0.70 | PIN1 (0.40) | SMN1; SMN2MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL17111315 | 0.70 | ALDH1A1 (0.38) | SMN1; SMN2MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL16726837 | 0.70 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL5972394 | 0.68 | MEN1 (0.40) | SMN1; SMN2MEN1KMT2AHTTTDP1 | |
| SCHEMBL27455916 | 0.68 | PIN1 (0.34) | SMN1; SMN2MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL11445122 | 0.68 | ALDH1A1 (0.45) | SMN1; SMN2MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL9705616 | 0.68 | MEN1 (0.45) | SMN1; SMN2MEN1KMT2AGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006441-B2 | Conjugate addition reactions using bifunctional cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2015-04-14 | — | — | US | disclosed |
| US-9006441-B2 | Conjugate addition reactions using bifunctional cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2015-04-14 | — | — | US | disclosed |
| US-20140249313-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | BRANDEIS UNIVERSITY (US) | 2014-09-04 | — | — | US | disclosed |
| US-20140249313-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | BRANDEIS UNIVERSITY (US) | 2014-09-04 | — | — | US | disclosed |
| US-8722891-B2 | Conjugate addition reactions using bifunctional Cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2014-05-13 | — | — | US | disclosed |
| US-8722891-B2 | Conjugate addition reactions using bifunctional Cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2014-05-13 | — | — | US | disclosed |
| US-20110295011-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | BRANDEIS UNIVERSITY (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110295011-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | BRANDEIS UNIVERSITY (US) | 2011-12-01 | — | — | US | disclosed |
| WO-2010077607-A2 | CONJUGATE ADDITION REACTIONS USING BIFUNCTIONAL CINCHONA-ALKALOID-BASED CATALYSTS | BRANDEIS UNIVERSITY (US) | 2010-07-08 | — | — | WO | disclosed |
| US-7582764-B2 | Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids | BRANDEIS UNIVERSITY (US) | 2009-09-01 | — | — | US | disclosed |
| US-20070083049-A1 | Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids | BRANDEIS UNIVERSITY (US) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070083049-A1 | Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids | ATIC, CBR3, IDH1 | SMN1; SMN2 4244/4885MEN1 3712/4885KMT2A 2237/4885 |
| US-20110295011-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | CPNE4, CPN1, NQO1 | SMN1; SMN2 4014/4885MEN1 792/4885KMT2A 2487/4885 |
| US-20140249313-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | CPNE4, CPN1, NQO1 | SMN1; SMN2 4014/4885MEN1 792/4885KMT2A 2487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.