Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120296 | 0.91 | CDK2 (0.53) | CDK2GSK3BEGLN1 | |
| SCHEMBL13120161 | 0.86 | CDK2 (0.51) | CDK2GSK3B | |
| SCHEMBL14545262 | 0.86 | CDK2 (0.45) | CDK2GSK3B | |
| SCHEMBL13288754 | 0.86 | CDK2 (0.45) | CDK2GSK3BNAMPT | |
| SCHEMBL13289132 | 0.86 | SIRT2 (0.45) | CDK2GSK3BNAMPT | |
| SCHEMBL14545970 | 0.84 | GSK3B (0.45) | CDK2GSK3B | |
| SCHEMBL13288895 | 0.84 | GSK3B (0.43) | CDK2GSK3BMAPK1 | |
| SCHEMBL13288867 | 0.83 | CDK2 (0.47) | CDK2GSK3B | |
| SCHEMBL13289235 | 0.82 | CDK2 (0.45) | CDK2GSK3BNAMPT | |
| SCHEMBL14545832 | 0.82 | CDK2 (0.48) | CDK2GSK3BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |