Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19388858 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2KCNQ2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL799896 | 0.84 | SMN1; SMN2 (0.70) | SMN1; SMN2TAS1R3TAS1R1ALDH1A1KMT2A | |
| SCHEMBL21103629 | 0.81 | KMT2A (0.57) | SMN1; SMN2ALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL14306608 | 0.79 | KDM4E (0.73) | ALDH1A1KMT2AKDM4EL3MBTL1NPC1 | |
| SCHEMBL17880836 | 0.79 | KDM4E (0.73) | ALDH1A1KMT2AKDM4EL3MBTL1NPC1 | |
| SCHEMBL27448738 | 0.79 | KCNQ2 (0.54) | SMN1; SMN2KCNQ2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL27641787 | 0.78 | KMT2A (0.51) | SMN1; SMN2KCNQ2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL10639437 | 0.78 | RAB9A (0.50) | SMN1; SMN2ALDH1A1KMT2AL3MBTL1NPC1 | |
| SCHEMBL1189632 | 0.78 | ALDH1A1 (0.77) | SMN1; SMN2ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL8089265 | 0.77 | ANPEP (0.52) | SMN1; SMN2KCNQ2TAS1R3TAS1R1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065085-A2 | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-06-10 | — | — | WO | disclosed |