Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.77 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 6/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.77 |
| ▸ | POLH | Q9Y253 | 5/20 | 0.77 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | XDH | P47989 | 4/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.77 |
| ▸ | IP6K2 | Q9UHH9 | 4/20 | 0.77 |
| ▸ | TP53 | P04637 | 4/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.77 |
| ▸ | MAOA | P21397 | 4/20 | 0.77 |
| ▸ | MAOB | P27338 | 4/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981018 | 0.89 | CYP1B1 (0.77) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| Luteolin SCHEMBL28336941 | 0.87 | POLH (0.94) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| Luteolin SCHEMBL28256564 | 0.87 | POLH (1.00) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| Luteolin SCHEMBL20426 | 0.87 | POLH (1.00) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| Luteolin SCHEMBL29352380 | 0.87 | POLH (1.00) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| Luteolin SCHEMBL30045580 | 0.87 | POLH (1.00) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| Luteolin SCHEMBL29376494 | 0.87 | POLH (1.00) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| SCHEMBL14144968 | 0.86 | POLH (0.58) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| SCHEMBL27462842 | 0.86 | MEN1 (0.76) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 | |
| Luteolin SCHEMBL1659262 | 0.86 | POLH (0.97) | CYP1B1CYP1A1CYP1A2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140050729-A1 | METHODS FOR TREATMENT OF POLYPOSIS | MERCK SHARP & DOHME (US) | 2014-02-20 | — | — | US | disclosed |
| US-20100143340-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100143340-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | TP53, KLK3, CD44 | CYP1B1 4850/4885CYP1A1 4730/4885CYP1A2 4691/4885 |
| US-20140050729-A1 | METHODS FOR TREATMENT OF POLYPOSIS | APC, FAP, MSH2 | CYP1B1 3036/4885CYP1A1 3967/4885CYP1A2 4494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.