Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17027045 | 0.83 | ALPL (0.49) | ELANECTSGPRTN3GAAALDH1A1 | |
| SCHEMBL4970309 | 0.78 | ALDH1A1 (0.48) | ELANECTSGPRTN3GAAALDH1A1 | |
| SCHEMBL19527553 | 0.77 | SCN9A (0.46) | ELANECTSGPRTN3GAAALDH1A1 | |
| SCHEMBL19527738 | 0.77 | REN (0.44) | ELANECTSGPRTN3GAAALDH1A1 | |
| SCHEMBL20752194 | 0.77 | ELANE (0.42) | ELANECTSGPRTN3GAAALDH1A1 | |
| SCHEMBL4969646 | 0.74 | POLB (0.61) | GAAALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL14303476 | 0.74 | MAPT (0.43) | GAAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16362032 | 0.74 | NISCH (0.52) | ELANECTSGPRTN3ALDH1A1MAPT | |
| SCHEMBL4755116 | 0.73 | ELANE (0.50) | ELANECTSGPRTN3ALDH1A1 | |
| SCHEMBL20752138 | 0.70 | SLC9A1 (0.52) | ELANECTSGPRTN3ALDH1A1NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049532-B1 | CGRP RECEPTOR ANTAGONISTS | VERTEX PHARMA (US) | 2010-06-02 | — | — | EP | disclosed |