Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 7/20 | 0.90 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | ESR1 | P03372 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | RECQL | P46063 | 2/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.73 |
| ▸ | FOS | P01100 | 2/20 | 0.73 |
| ▸ | TTR | P02766 | 2/20 | 0.73 |
| ▸ | JUN | P05412 | 2/20 | 0.73 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.73 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylnordihydroguarierate Acid SCHEMBL22039401 | 0.95 | ALOX15 (1.00) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| SCHEMBL22040032 | 0.92 | ALOX15 (1.00) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| SCHEMBL29929344 | 0.90 | ALOX15 (1.00) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| SCHEMBL4640898 | 0.90 | ALOX15 (0.90) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| SCHEMBL13309003 | 0.90 | ALOX15 (1.00) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| SCHEMBL29794171 | 0.90 | ALOX15 (1.00) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| SCHEMBL4639890 | 0.90 | ALOX15 (1.00) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| SCHEMBL26300965 | 0.87 | ALOX15 (0.84) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| Nordihydroguaiaretic Acid SCHEMBL135976 | 0.86 | ALOX15 (1.00) | ALOX15ALOX12CYP3A4MEN1KMT2A | |
| Nordihydroguaiaretic Acid SCHEMBL13906133 | 0.86 | ALOX15 (1.00) | ALOX15ALOX12CYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40246-E1 | Method for the suppression of viral growth | JOHN HOPKINS UNIVERSITY (US) | 2008-04-15 | — | — | US | claimed |
| EP-3663295-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | ELI LILLY AND CO. (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3184527-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | LILLY CO ELI (US) | 2020-01-29 | — | — | EP | disclosed |
| US-10351567-B2 | Methods and compositions for treating pain | ELI LILLY AND COMPANY (US) | 2019-07-16 | — | — | US | disclosed |
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | ELI LILLY AND COMPANY | 2018-05-17 | — | — | US | disclosed |
| US-20180093986-A1 | METHODS AND COMPOSITIONS FOR TREATING PAIN | HYDRA BIOSCIENCES, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| US-20180051020-A1 | COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO TRPA1 | HYDRA BIOSCIENCES INC (US) | 2018-02-22 | — | — | US | disclosed |
| US-9815838-B2 | Methods and compositions for treating pain | HYDRA BIOSCIENCES, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170224687-A1 | COMPOUNDS FOR MODULATING TRPV3 FUNCTION | HYDRA BIOSCIENCES INC (US) | 2017-08-10 | — | — | US | disclosed |
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| US-20060141046-A1 | Particles for the delivery of active agents | IVREA PHARMACEUTICALS, INC. (US) | 2006-06-29 | — | — | US | disclosed |
| US-20050281886-A1 | Particles for the delivery of active agents | IVREA PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | disclosed |
| WO-2005107710-A2 | PARTICLES FOR THE DELIVERY OF ACTIVE AGENTS | IVREA PHARMACEUTICALS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |
| US-6365787-B1 | CREOSOTE BUSH LARREA TRIDENTATA EXTRACTS OF 1,4-BIS-(3,4-DIHYDROXY-PHENYL)-2,3-DIMETHYLBUTANE DERIVATIVES | THE JOHNS HOPKINS UNIVERSITY | 2002-04-02 | — | — | US | disclosed |
| US-6291524-B1 | HYDROXY-, METHOXY- AND ACETOXY-DERIVATIVES OF 2,3-DIMETHYL-1,4-DIPHENYLBUTANE | JOHNS HOPKINS UNIVERSITY | 2001-09-18 | — | — | US | disclosed |
| US-5663209-A | Compounds for the suppression of HIV Tat transactivation | THE JOHNS HOPKINS UNIVERSITY (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0783474-A4 | — | — | 1997-08-27 | — | — | EP | disclosed |
| EP-0783474-A1 | COMPOUNDS FOR THE SUPPRESSION OF HIV TAT TRANSACTIVATION | THE JOHNS-HOPKINS UNIVERSITY (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010549-A9 | COMPOUNDS FOR THE SUPPRESSION OF HIV TAT TRANSACTIVATION | — | 1996-06-06 | — | — | WO | disclosed |
| WO-1996010549-A1 | COMPOUNDS FOR THE SUPPRESSION OF HIV TAT TRANSACTIVATION | THE JOHNS-HOPKINS UNIVERSITY (US) | 1996-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180051020-A1 | COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO TRPA1 | TRPA1, TRPV1, TRPV2 | ALOX15 298/4885ALOX12 246/4885CYP3A4 2908/4885 |
| US-20170224687-A1 | COMPOUNDS FOR MODULATING TRPV3 FUNCTION | TRPV3, TRPV1, TRPV4 | ALOX15 1047/4885ALOX12 736/4885CYP3A4 3177/4885 |
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | TRPA1, TRPV1, TRPV3 | ALOX15 148/4885ALOX12 90/4885CYP3A4 2805/4885 |
| US-10351567-B2 | Methods and compositions for treating pain | ACHE, COL2A1, MMP8 | ALOX15 91/4885ALOX12 66/4885CYP3A4 3970/4885 |
| US-20180093986-A1 | METHODS AND COMPOSITIONS FOR TREATING PAIN | ACHE, COL2A1, MMP8 | ALOX15 91/4885ALOX12 66/4885CYP3A4 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.