Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 7/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 7/20 | 1.00 |
| ▸ | FOS | P01100 | 2/20 | 0.76 |
| ▸ | TTR | P02766 | 2/20 | 0.76 |
| ▸ | JUN | P05412 | 2/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.76 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.76 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | ESR1 | P03372 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | RECQL | P46063 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29794171 | 0.92 | ALOX15 (1.00) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL29929344 | 0.92 | ALOX15 (1.00) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL13309003 | 0.92 | ALOX15 (1.00) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL4639890 | 0.92 | ALOX15 (1.00) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL2390 | 0.92 | FOS (0.90) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL16917560 | 0.92 | FOS (0.90) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL3160 | 0.92 | ALOX15 (0.90) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL4640898 | 0.92 | ALOX15 (0.90) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL31237435 | 0.92 | FOS (0.90) | ALOX15ALOX12FOSTTRJUN | |
| Terameprocol SCHEMBL2356280 | 0.88 | ALOX15 (0.77) | ALOX15ALOX12FOSTTRJUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11744820-B2 | Inhibitors of microbially induced amyloid | AXIAL THERAPEUTICS, INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-11744820-B2 | Inhibitors of microbially induced amyloid | AXIAL THERAPEUTICS, INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-11147792-B2 | Inhibitors of microbially induced amyloid | AXIAL THERAPEUTICS, INC. (US) | 2021-10-19 | — | — | US | disclosed |
| US-20200163933-A1 | INHIBITORS OF MICROBIALLY INDUCED AMYLOID | AXIAL BIOTHERAPEUTICS, INC. | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11744820-B2 | Inhibitors of microbially induced amyloid | APP, PSEN1, BACE1 | ALOX15 684/4885ALOX12 726/4885FOS 799/4885 |
| US-20200163933-A1 | INHIBITORS OF MICROBIALLY INDUCED AMYLOID | APP, PSEN1, BACE1 | ALOX15 684/4885ALOX12 726/4885FOS 799/4885 |
| US-11147792-B2 | Inhibitors of microbially induced amyloid | APP, PSEN1, BACE1 | ALOX15 684/4885ALOX12 726/4885FOS 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.