Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3886209 | 0.75 | IDO1 (0.47) | ALDH1A1KDM4EMAPTL3MBTL1RAB9A | |
| SCHEMBL5218956 | 0.75 | MAOA (0.57) | ALDH1A1KDM4EMAPTL3MBTL1RAB9A | |
| SCHEMBL30422223 | 0.75 | ALOX5 (0.43) | ALDH1A1KDM4EMAPTL3MBTL1RAB9A | |
| SCHEMBL3636775 | 0.75 | ALOX5 (0.43) | ALDH1A1KDM4EMAPTL3MBTL1RAB9A | |
| SCHEMBL3292618 | 0.72 | CTSB (0.54) | ALDH1A1KDM4EMAPTRAB9ANPC1 | |
| SCHEMBL13311444 | 0.71 | TNKS (0.33) | ALDH1A1MAPTL3MBTL1TNKSTNKS2 | |
| SCHEMBL8078642 | 0.71 | MAPT (0.57) | ALDH1A1MAPTL3MBTL1RAB9ANPSR1 | |
| SCHEMBL28757870 | 0.71 | AKR1B1 (0.46) | ALDH1A1KDM4ERAB9ATDP1ALOX5 | |
| SCHEMBL2126343 | 0.70 | MAOA (0.51) | ALDH1A1KDM4EMAPTL3MBTL1RAB9A | |
| SCHEMBL1615170 | 0.70 | MAOB (0.51) | ALDH1A1KDM4EMAPTL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732483-B2 | DNA-PK inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-06-08 | — | — | US | disclosed |
| US-20080242664-A1 | DNA-PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-10-02 | — | — | US | disclosed |
| US-7402607-B2 | DNA-PK inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242664-A1 | DNA-PK INHIBITORS | XRCC6, XRCC5, POLK | ALDH1A1 4383/4885KDM4E 378/4885MAPT 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.