Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452030 | 1.00 | ALDH1A1 (0.54) | ALDH1A1KMT2AHSD17B10HPGDGAA | |
| SCHEMBL1436043 | 0.90 | ALDH1A1 (0.56) | ALDH1A1KMT2AHSD17B10HPGDPOLB | |
| SCHEMBL30984472 | 0.90 | ALDH1A1 (0.56) | ALDH1A1KMT2AHSD17B10HPGDPOLB | |
| SCHEMBL14594063 | 0.89 | KMT2A (0.60) | ALDH1A1KMT2AHSD17B10HPGDGAA | |
| SCHEMBL10425510 | 0.88 | HDAC8 (0.61) | ALDH1A1KMT2AHPGDPOLBSMN1; SMN2 | |
| SCHEMBL11661610 | 0.87 | HDAC8 (0.64) | ALDH1A1KMT2AHPGDPOLBSMN1; SMN2 | |
| SCHEMBL11464787 | 0.87 | HDAC8 (0.64) | ALDH1A1KMT2AHPGDPOLBSMN1; SMN2 | |
| SCHEMBL8118590 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KMT2AHSD17B10HPGDGAA | |
| SCHEMBL4403950 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KMT2AHSD17B10HPGDGAA | |
| SCHEMBL31065934 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KMT2AHSD17B10HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589606-B1 | TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF ALPHA-HALO-ACRYLIC ACID DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2023-09-20 | — | — | EP | disclosed |
| CN-110366547-B | Transition metal catalyzed photodecarboxylation of alpha-haloacrylic acid derivatives | 勃林格殷格翰国际有限公司 | 2023-02-17 | — | — | CN | disclosed |
| US-11046648-B2 | Transition metal-catalyzed protodecarboxylation of α-halo-acrylic acid derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-06-29 | — | — | US | disclosed |
| US-20200231544-A1 | Transition Metal-catalyzed Protodecarboxylation of alpha-Halo-acrylic Acid Derivatives | BOEHRINGER INGELHEIM INT (DE) | 2020-07-23 | — | — | US | disclosed |
| CN-107635992-B | Tricyclic heterocyclic compounds useful as TNF inhibitors | 百时美施贵宝公司 | 2020-05-22 | — | — | CN | disclosed |
| US-10654803-B2 | Transition metal-catalyzed protodecarboxylation of alpha-halo-acrylic acid derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-05-19 | — | — | US | disclosed |
| EP-3271361-B1 | TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF | BRISTOL MYERS SQUIBB CO (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3271361-B1 | TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF | BRISTOL MYERS SQUIBB CO (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |
| US-20190177273-A1 | TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF ALPHA-HALO-ACRYLIC ACID DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2019-06-13 | — | — | US | disclosed |
| US-5190589-A | Compounds and process preparing a substituted or an unsubstituted 4(5)-(ω-aminoalkyl)imidazole | CEDONA PHARMACEUTICALS B.V. (NL) | 1993-03-02 | — | — | US | disclosed |
| EP-0511270-A1 | NEW THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1992-11-04 | — | — | EP | disclosed |
| US-5037834-A | Heterocycylic-substituted quinoline-carboxylic acids | PFIZER INC. (US) | 1991-08-06 | — | — | US | disclosed |
| WO-1991010657-A1 | NEW THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-07-25 | — | — | WO | disclosed |
| EP-0415948-A1 | PROCESS FOR PREPARING A SUBSTITUTED OR AN UNSUBSTITUTED 4(5)-($g(v)-AMINOALKYL)IMIDAZOLE | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989010360-A1 | PROCESS FOR PREPARING A SUBSTITUTED OR AN UNSUBSTITUTED 4(5)-(omega-AMINOALKYL)IMIDAZOLE | CEDONA PHARMACEUTICALS B.V. (NL) | 1989-11-02 | — | — | WO | disclosed |
| WO-1989005643-A1 | HETEROCYCLIC-SUBSTITUTED QUINOLINE-CARBOXYLIC ACIDS | PFIZER INC. (US) | 1989-06-29 | — | — | WO | disclosed |
| EP-0321191-A2 | Heterocyclic-substituted quinoline-carboxylic acids | PFIZER INC. (US) | 1989-06-21 | — | — | EP | disclosed |
| US-4548935-A | Dihydropyridine anti-ischaemic and anti-hypertensive agents, compositions and use | PFIZER INC. (US) | 1985-10-22 | — | — | US | disclosed |
| EP-0150939-A1 | Dihydropyridine anti-ischaemic and antihypertensive agents | Pfizer Limited (GB) | 1985-08-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231544-A1 | Transition Metal-catalyzed Protodecarboxylation of alpha-Halo-acrylic Acid Derivatives | HDHD5, HACL2, ALAD | ALDH1A1 371/4885KMT2A 1215/4885HSD17B10 183/4885 |
| US-10654803-B2 | Transition metal-catalyzed protodecarboxylation of alpha-halo-acrylic acid derivatives | HACL2, HDHD5, HCAR1 | ALDH1A1 117/4885KMT2A 2016/4885HSD17B10 180/4885 |
| US-11046648-B2 | Transition metal-catalyzed protodecarboxylation of α-halo-acrylic acid derivatives | HDHD5, HACL2, ALAD | ALDH1A1 331/4885KMT2A 1112/4885HSD17B10 173/4885 |
| US-20190177273-A1 | TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF ALPHA-HALO-ACRYLIC ACID DERIVATIVES | HDHD5, HACL2, ALAD | ALDH1A1 371/4885KMT2A 1215/4885HSD17B10 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.