Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30984472 | 1.00 | ALDH1A1 (0.56) | ALDH1A1ACHEHDAC8HDAC3HDAC4 | |
| SCHEMBL10425510 | 0.95 | HDAC8 (0.61) | ALDH1A1ACHEHDAC8HDAC3HDAC4 | |
| SCHEMBL11661610 | 0.94 | HDAC8 (0.64) | ALDH1A1HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL11464787 | 0.94 | HDAC8 (0.64) | ALDH1A1HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL133129 | 0.90 | ALDH1A1 (0.54) | ALDH1A1HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL29452030 | 0.90 | ALDH1A1 (0.54) | ALDH1A1HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL11754615 | 0.90 | ALDH1A1 (0.62) | ALDH1A1ACHEHDAC8HDAC3HDAC4 | |
| SCHEMBL11208262 | 0.83 | ALDH1A1 (0.56) | ALDH1A1ACHEHDAC8HDAC3HDAC4 | |
| SCHEMBL29986677 | 0.83 | ALDH1A1 (0.56) | ALDH1A1ACHEHDAC8HDAC3HDAC4 | |
| SCHEMBL10672732 | 0.83 | ALDH1A1 (0.56) | ALDH1A1ACHEHDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9605297-B2 | Method of generating linkage-specific di-and polyprotein probes | UNIVERSITY OF DELAWARE (US) | 2017-03-28 | — | — | US | disclosed |
| US-9605297-B2 | Method of generating linkage-specific di-and polyprotein probes | UNIVERSITY OF DELAWARE (US) | 2017-03-28 | — | — | US | disclosed |
| US-20160237471-A1 | METHOD OF GENERATING LINKAGE-SPECIFIC DI-AND POLYPROTEIN PROBES | Universtiy of Delaware (US) | 2016-08-18 | — | — | US | disclosed |
| US-20160237471-A1 | METHOD OF GENERATING LINKAGE-SPECIFIC DI-AND POLYPROTEIN PROBES | Universtiy of Delaware (US) | 2016-08-18 | — | — | US | disclosed |
| US-9084423-B2 | Inhibition of bacterial biofilms with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-07-21 | — | — | US | disclosed |
| WO-2015057803-A1 | METHOD OF GENERATING LINKAGE-SPECIFIC DI-AND POLYPROTEIN PROBES | ZHUANG ZHIHAO (US) | 2015-04-23 | — | — | WO | disclosed |
| US-8927029-B2 | Inhibition of biofilms in plants with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-01-06 | — | — | US | disclosed |
| US-20140127273-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140079808-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-03-20 | — | — | US | disclosed |
| US-8653124-B2 | Inhibition of bacterial biofilms with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| WO-2003097053-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |
| US-20030130281-A1 | DPP IV inhibitors | HOFFMAN-LA ROCHE INC. | 2003-07-10 | — | — | US | disclosed |
| WO-2003037327-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA-ROCHE AG (CH) | 2003-05-08 | — | — | WO | disclosed |
| US-5190589-A | Compounds and process preparing a substituted or an unsubstituted 4(5)-(ω-aminoalkyl)imidazole | CEDONA PHARMACEUTICALS B.V. (NL) | 1993-03-02 | — | — | US | disclosed |
| EP-0511270-A1 | NEW THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1992-11-04 | — | — | EP | disclosed |
| WO-1991010657-A1 | NEW THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-07-25 | — | — | WO | disclosed |
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0415948-A1 | PROCESS FOR PREPARING A SUBSTITUTED OR AN UNSUBSTITUTED 4(5)-($g(v)-AMINOALKYL)IMIDAZOLE | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989010360-A1 | PROCESS FOR PREPARING A SUBSTITUTED OR AN UNSUBSTITUTED 4(5)-(omega-AMINOALKYL)IMIDAZOLE | CEDONA PHARMACEUTICALS B.V. (NL) | 1989-11-02 | — | — | WO | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237471-A1 | METHOD OF GENERATING LINKAGE-SPECIFIC DI-AND POLYPROTEIN PROBES | USP28, USP36, STUB1 | ALDH1A1 2154/4885ACHE 3293/4885HDAC8 710/4885 |
| US-20140079808-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | ITPA, SOD1, ICMT | ALDH1A1 2079/4885ACHE 92/4885HDAC8 244/4885 |
| US-20140127273-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | O60361, TFPI, BLVRB | ALDH1A1 3424/4885ACHE 874/4885HDAC8 377/4885 |
| US-20030130281-A1 | DPP IV inhibitors | DPP4, DPP3, DPP7 | ALDH1A1 133/4885ACHE 847/4885HDAC8 2719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.