Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316589 | 0.77 | METTL3 (0.43) | CSF1REGFRMPOKMT2AMEN1 | |
| SCHEMBL13349641 | 0.77 | METTL3 (0.38) | CSF1REGFRKMT2AMEN1METTL3 | |
| SCHEMBL13349640 | 0.77 | METTL3 (0.40) | CSF1REGFRKMT2AMEN1METTL3 | |
| SCHEMBL13316625 | 0.75 | MPO (0.41) | MPOKMT2AKCNH2HTT | |
| SCHEMBL13349605 | 0.74 | METTL3 (0.36) | CSF1REGFRKMT2AMEN1SRC | |
| SCHEMBL13316676 | 0.74 | P2RX7 (0.34) | PDE10ACSF1REGFRMETTL3 | |
| SCHEMBL13349627 | 0.74 | METTL3 (0.38) | CSF1REGFRKMT2AMEN1METTL3 | |
| SCHEMBL13316614 | 0.73 | CYP3A4 (0.42) | MPO | |
| SCHEMBL15453555 | 0.71 | LMNA (0.46) | KMT2AMEN1KDM4EALDH1A1MAPK1 | |
| SCHEMBL1104892 | 0.70 | HTR2A (0.46) | MPOTAAR1KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |