Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | FPR1 | P21462 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13323939 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1NPBWR1 | |
| SCHEMBL13323912 | 0.84 | MAPT (0.44) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1NPBWR1 | |
| SCHEMBL13324015 | 0.83 | ALOX5 (0.37) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1NPBWR1 | |
| SCHEMBL13323884 | 0.83 | NPBWR1 (0.48) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1NPBWR1 | |
| SCHEMBL13324025 | 0.82 | NPBWR1 (0.43) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1NPBWR1 | |
| SCHEMBL10072551 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1KDM4E | |
| SCHEMBL13323954 | 0.75 | PPARG (0.39) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1NPBWR1 | |
| SCHEMBL7918572 | 0.72 | PTGS2 (0.51) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1NPC1 | |
| SCHEMBL13323993 | 0.69 | NPBWR1 (0.38) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1NPBWR1 | |
| SCHEMBL11965003 | 0.68 | PDE9A (0.38) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718612-B2 | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20090035272-A1 | Pyridazinonyl Macrocyclic Hepatitis C Serine Protease Inhibitors | ENANTA PHARMACEUTICALS, INC. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090035272-A1 | Pyridazinonyl Macrocyclic Hepatitis C Serine Protease Inhibitors | PRSS1, SPINT2, TMPRSS4 | SMN1; SMN2 3333/4885CYP1A2 241/4885CYP2C19 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.