SCHEMBL133345

SCHEMBL133345

Cc1cc(C)c(Br)cc1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.47
CYP3A4 P08684 1/20 0.47
MAPK1 P28482 1/20 0.47
ALDH1A1 P00352 2/20 0.38
BCHE P06276 1/20 0.38
CES1 P23141 1/20 0.38
POLB P06746 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
LMNA P02545 1/20 0.37
HTR2C P28335 2/20 0.32
KDM1A O60341 2/20 0.32
KDM1B Q8NB78 1/20 0.32
NPC1 O15118 1/20 0.32
NR2F2 P24468 1/20 0.32
NOD2 Q9HC29 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NQO2 P16083 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29366549 1.00 TSHR (0.47) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL120851 0.93 ALDH1A1 (0.42) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL482796 0.89 TSHR (0.42) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL11045804 0.86 ALDH1A1 (0.38) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL29637482 0.85 TSHR (0.44) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL1135594 0.85 TSHR (0.44) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL19831167 0.80 BCHE (0.45) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL14866666 0.80 BCHE (0.45) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL272760 0.78 CYP3A4 (0.63) TSHRCYP3A4MAPK1ALDH1A1BCHE
SCHEMBL31387618 0.78 CYP3A4 (0.63) TSHRCYP3A4MAPK1ALDH1A1BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 189 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115490658-B Preparation method of 4,4' -oxydiphthalic anhydride 天津众泰材料科技有限公司 2023-11-14 CN claimed
CN-115490658-A Preparation method of 4,4' -oxydiphthalic anhydride 天津众泰材料科技有限公司 2022-12-20 CN claimed
US-12479849-B2 EGFR inhibitors for the treatment of cancer HOFFMANN-LA ROCHE INC. (US) 2025-11-25 US disclosed
EP-4065566-B1 TRPM8 MODULATORS GIVAUDAN SA (CH) 2025-01-01 EP disclosed
EP-4426679-A1 SPIRO-(INDANE-FLUORENE) TYPE COMPOUNDS AND THEIR USE IN ORGANIC ELECTRONICS DOTTIKON ES HOLDING AG (CH) 2024-09-11 EP disclosed
CN-118251380-A Spiro- (indan-fluorene) compounds and their use in organic electronic devices 多蒂肯独家合成控股公司 2024-06-25 CN disclosed
US-11917912-B2 Organic compound, organic light-emitting element, display apparatus, photoelectric conversion apparatus, electronic apparatus, illumination apparatus, moving object, and exposure light source CANON KABUSHIKI KAISHA (JP) 2024-02-27 US disclosed
CN-117466745-A Method for synthesizing arylamine compound by using photochemical manganese as catalyst 陕西师范大学 2024-01-30 CN disclosed
CN-115490658-B Preparation method of 4,4' -oxydiphthalic anhydride 天津众泰材料科技有限公司 2023-11-14 CN disclosed
WO-2023078824-A1 SPIRO-(INDANE-FLUORENE) TYPE COMPOUNDS AND THEIR USE IN ORGANIC ELECTRONICS DOTTIKON ES HOLDING AG (CH) 2023-05-11 WO disclosed
EP-3986896-B1 EGFR INHIBITORS FOR THE TREATMENT OF CANCER HOFFMANN LA ROCHE (CH) 2023-03-15 EP disclosed
EP-0537223-A1 NEW 6-ARYL-6H-DIBENZO-[c,e][1,2]-OXAPHOSPHORINES, A METHOD FOR PREPARING THEM, AND THEIR USE FOR THE STABILIZATION OF PLASTICS, IN PARTICULAR POLYOLEFIN MOULDING MATERIALS. HOECHST AG (DE) 1993-04-21 EP disclosed
EP-0489050-A1 ARYL ESTER AMIDE HALIDES OF PHOSPHONOUS ACID, ARYL ESTER AMIDES OF PHOSPHONOUS ACID, PROCESS FOR PREPARING THEM AND THEIR USE TO STABILIZE PLASTICS HOECHST AKTIENGESELLSCHAFT (DE) 1992-06-10 EP disclosed
EP-0472564-A1 ARYLESTERS OF PHOSPHONOUS ACID, PROCESS FOR PREPARING THEM AND THEIR USE TO STABILIZE PLASTICS, IN PARTICULAR POLYOLEFIN MOULDING MATERIALS. HOECHST AG (DE) 1992-03-04 EP disclosed
WO-1992000306-A1 NEW 6-ARYL-6H-DIBENZO-[c,e][1,2]-OXAPHOSPHORINES, A METHOD FOR PREPARING THEM, AND THEIR USE FOR THE STABILIZATION OF PLASTICS, IN PARTICULAR POLYOLEFIN MOULDING MATERIALS HOECHST AKTIENGESELLSHAFT (DE) 1992-01-09 WO disclosed
WO-1992000304-A1 NEW PHOSPHONIC ACID ARYL ESTER HALIDES AND A METHOD FOR PREPARING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1992-01-09 WO disclosed
WO-1991002738-A1 ARYL ESTER AMIDE HALIDES OF PHOSPHONOUS ACID, ARYL ESTER AMIDES OF PHOSPHONOUS ACID, PROCESS FOR PREPARING THEM AND THEIR USE TO STABILIZE PLASTICS HOECHST AKTIENGESELLSCHAFT (DE) 1991-03-07 WO disclosed
WO-1990014349-A2 ARYLESTERS OF PHOSPHONOUS ACID, PROCESS FOR PREPARING THEM AND THEIR USE TO STABILIZE PLASTICS, IN PARTICULAR POLYOLEFIN MOULDING MATERIALS HOECHST AKTIENGESELLSCHAFT (DE) 1990-11-29 WO disclosed
US-4330473-A FLUORAN COLOR-FORMER YAMAMOTO KAGAKU GOSEI KABUSHIKI KAISHA (JP) 1982-05-18 US disclosed
US-3960538-A INHIBITION OF ALGAE MILLMASTER ONYX CORPORATION (US) 1976-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11917912-B2 Organic compound, organic light-emitting element, display apparatus, photoelectric conversion apparatus, electronic apparatus, illumination apparatus, moving object, and exposure light source AOX1, SOD1, L1CAM TSHR 1720/4885CYP3A4 611/4885MAPK1 1240/4885
US-12479849-B2 EGFR inhibitors for the treatment of cancer EGFR, ERBB2, ERBB3 TSHR 217/4885CYP3A4 3802/4885MAPK1 728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.