Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18762839 | 0.82 | HRH3 (0.84) | HRH3TAAR1CHRNA7KCNH2AOC3 | |
| SCHEMBL28906274 | 0.76 | CA2 (0.47) | ALDH1A1MAPTKMT2A | |
| SCHEMBL3057063 | 0.73 | HRH3 (0.70) | HRH3TAAR1CHRNA7KCNH2AOC3 | |
| SCHEMBL3046909 | 0.73 | HRH3 (0.70) | HRH3TAAR1CHRNA7KCNH2CYP1A2 | |
| SCHEMBL3059072 | 0.73 | HRH3 (0.70) | HRH3TAAR1CHRNA7KCNH2AOC3 | |
| SCHEMBL1975214 | 0.73 | HRH3 (0.70) | HRH3TAAR1CHRNA7KCNH2ALDH1A1 | |
| SCHEMBL26355428 | 0.72 | HRH3 (0.61) | HRH3TAAR1CHRNA7KCNH2AOC3 | |
| SCHEMBL31189352 | 0.72 | ALDH1A1 (0.52) | ALDH1A1TP53 | |
| SCHEMBL10262063 | 0.71 | HRH3 (0.67) | HRH3TAAR1ALDH1A1 | |
| SCHEMBL189454 | 0.71 | HRH3 (0.67) | HRH3TAAR1AOC3SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871916-B2 | Diaryl phosphine compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-8871916-B2 | Diaryl phosphine compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20130203974-A1 | Preparation of Diazo and Diazonium Compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-08-08 | — | — | US | disclosed |
| US-20130203974-A1 | Preparation of Diazo and Diazonium Compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-08-08 | — | — | US | disclosed |
| US-8410247-B2 | Water-soluble phosphinothiol reagents | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410247-B2 | Water-soluble phosphinothiol reagents | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-02 | — | — | US | disclosed |
| US-8350014-B2 | Preparation of diazo and diazonium compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-01-08 | — | — | US | disclosed |
| US-8350014-B2 | Preparation of diazo and diazonium compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-01-08 | — | — | US | disclosed |
| US-20100125132-A1 | PREPARATION OF DIAZO AND DIAZONIUM COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-05-20 | — | — | US | disclosed |
| US-20100125132-A1 | PREPARATION OF DIAZO AND DIAZONIUM COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-05-20 | — | — | US | disclosed |
| US-20100048866-A1 | WATER-SOLUBLE PHOSPHINOTHIOL REAGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125132-A1 | PREPARATION OF DIAZO AND DIAZONIUM COMPOUNDS | TREH, TALDO1, LIPE | HRH3 2078/4885TAAR1 1615/4885CHRNA7 1867/4885 |
| US-20130203974-A1 | Preparation of Diazo and Diazonium Compounds | TREH, TALDO1, LIPE | HRH3 2078/4885TAAR1 1615/4885CHRNA7 1867/4885 |
| US-20100048866-A1 | WATER-SOLUBLE PHOSPHINOTHIOL REAGENTS | PTMS, PHOSPHO1, ACP1 | HRH3 3184/4885TAAR1 840/4885CHRNA7 4789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.