Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939671 | 0.94 | ROCK2 (0.35) | LMNAMEN1CYP2C19RECQLKMT2A | |
| SCHEMBL18354358 | 0.92 | TP53 (0.34) | LMNAMEN1CYP2C19RECQLKMT2A | |
| SCHEMBL18354412 | 0.92 | TP53 (0.34) | LMNAMEN1CYP2C19RECQLKMT2A | |
| SCHEMBL18354410 | 0.92 | TP53 (0.34) | LMNAMEN1CYP2C19RECQLKMT2A | |
| SCHEMBL3784779 | 0.90 | SHBG (0.40) | LMNACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL27675099 | 0.87 | CHRNB2 (0.32) | LMNAALOX5CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27675100 | 0.87 | CHRNB2 (0.32) | LMNAALOX5CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL28771692 | 0.86 | CPN1 (0.41) | LMNACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL25293694 | 0.85 | LMNA (0.32) | LMNAMEN1CYP2C19RECQLKMT2A | |
| SCHEMBL28377083 | 0.84 | LMNA (0.32) | LMNAMEN1CYP2C19RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113479-A1 | PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL AS GDIR AGONISTS | ARENA PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
| US-20100113480-A1 | PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL AS GDIR AGONISTS | ARENA PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113479-A1 | PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL AS GDIR AGONISTS | GPR119, GCGR, GIPR | LMNA 4294/4885MEN1 4615/4885CYP2C19 947/4885 |
| US-20100113480-A1 | PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL AS GDIR AGONISTS | GPR119, GCGR, GIPR | LMNA 4294/4885MEN1 4615/4885CYP2C19 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.