Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | ABL2 | P42684 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.33 |
| ▸ | STK17B | O94768 | 2/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.33 |
| ▸ | DAPK2 | Q9UIK4 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1335870 | 1.00 | ADH1A (0.49) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL12126154 | 0.97 | ADH1A (0.46) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL15493624 | 0.91 | ADH1A (0.46) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL1335694 | 0.91 | ADH1A (0.44) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL6518872 | 0.91 | ADH1A (0.53) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL6518871 | 0.91 | ADH1A (0.53) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL14301821 | 0.90 | PYGL (0.38) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL6512534 | 0.88 | KDR (0.52) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL6512526 | 0.88 | KDR (0.52) | ADH1AKITFLT1KDRABL2 | |
| SCHEMBL13669050 | 0.88 | ADH1A (0.50) | ADH1AKITFLT1KDRABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110280890-A1 | PRODRUGS OF CC-1065 ANALOGS | IMMUNOGEN, INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-8012978-B2 | Prodrugs of CC-A1065 analogs | IMMUNOGEN, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-20090028821-A1 | PRODRUGS OF CC-A1065 ANALOGS | SANOFI-AVENTIS (FR) | 2009-01-29 | — | — | US | disclosed |
| EP-1993999-A1 | IMPROVED PRODRUGS OF CC-1065 ANALOGS | Sanofi-Aventis (FR) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007102069-A1 | IMPROVED PRODRUGS OF CC-1065 ANALOGS | SANOFI-AVENTIS (FR) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110280890-A1 | PRODRUGS OF CC-1065 ANALOGS | CASP5, SENP5, CWC15 | ADH1A 4088/4885KIT 2815/4885FLT1 1259/4885 |
| US-20090028821-A1 | PRODRUGS OF CC-A1065 ANALOGS | PDIA5, CA6, STS | ADH1A 2353/4885KIT 3779/4885FLT1 1380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.