Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 12/20 | 0.57 |
| ▸ | CACNA1I | Q9P0X4 | 12/20 | 0.57 |
| ▸ | CACNA1H | O95180 | 11/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359484 | 0.87 | ADORA1 (0.46) | CACNA1GCACNA1ICACNA1HALDH1A1LMNA | |
| SCHEMBL13359475 | 0.87 | POLB (0.53) | CACNA1GCACNA1IALDH1A1LMNACDK5 | |
| SCHEMBL13359538 | 0.85 | CYP11B1 (0.46) | CACNA1GCACNA1ICACNA1HALDH1A1LMNA | |
| SCHEMBL13359440 | 0.83 | BRD4 (0.46) | CACNA1GCACNA1ICACNA1HALDH1A1LMNA | |
| SCHEMBL13359474 | 0.81 | RAB9A (0.44) | CACNA1GCACNA1ICACNA1HALDH1A1 | |
| SCHEMBL13359443 | 0.79 | ELOVL1 (0.52) | ALDH1A1LMNATSHRELOVL1 | |
| SCHEMBL13359536 | 0.78 | CASP3 (0.43) | CACNA1GCACNA1ICACNA1HALDH1A1LMNA | |
| SCHEMBL13359471 | 0.78 | HPGD (0.42) | LMNA | |
| SCHEMBL13359488 | 0.74 | ATM (0.53) | ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL13325242 | 0.69 | MAPK8 (0.46) | CACNA1GCACNA1ICACNA1HALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718686-B2 | Imidazole variants as modulators of GABA receptor for the treatment of GI disorders | ASTRAZENECA AB (SE) | 2010-05-18 | — | — | US | disclosed |
| US-20080269216-A1 | Imidazole Variants as Modulators of Gaba Receptor For the Treatment of Gi Disorders | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269216-A1 | Imidazole Variants as Modulators of Gaba Receptor For the Treatment of Gi Disorders | GABRB1, GABBR2, GABBR1 | CACNA1G 681/4885CACNA1I 526/4885CACNA1H 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.