Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | GLS | O94925 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10671178 | 0.90 | KMT2A (0.54) | KMT2APKMALDH1A1HPGDGAA | |
| SCHEMBL2084857 | 0.89 | ALDH1A1 (0.59) | KMT2AALDH1A1HSD17B10MEN1HDAC8 | |
| SCHEMBL29740524 | 0.89 | ALDH1A1 (0.59) | KMT2AALDH1A1HSD17B10MEN1HDAC8 | |
| SCHEMBL7443883 | 0.87 | HDAC8 (0.65) | KMT2AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL10495286 | 0.86 | HDAC8 (0.68) | KMT2AALDH1A1HPGDGAAMEN1 | |
| SCHEMBL10913404 | 0.86 | HDAC8 (0.68) | KMT2AALDH1A1HPGDGAAMEN1 | |
| Ethylene SCHEMBL9101813 | 0.86 | ALDH1A1 (0.56) | KMT2AALDH1A1HSD17B10MEN1HDAC8 | |
| Ethylene Glycol SCHEMBL7141967 | 0.84 | ALDH1A1 (0.55) | KMT2AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL10018578 | 0.84 | MEN1 (0.66) | KMT2AALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL14594063 | 0.84 | KMT2A (0.60) | KMT2AALDH1A1HPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521289-B1 | MNK INHIBITORS AND METHODS RELATED THERETO | EFFECTOR THERAPEUTICS INC (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |
| US-20210338673-A1 | MNK INHIBITORS AND METHODS RELATED THERETO | EFFECTOR THERAPEUTICS INC (US) | 2021-11-04 | — | — | US | disclosed |
| US-11044931-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | BASF SE (DE) | 2021-06-29 | — | — | US | disclosed |
| US-11044931-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | BASF SE (DE) | 2021-06-29 | — | — | US | disclosed |
| EP-2758041-B1 | LOW-MOLECULAR MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE OF SAME | BASF SE (DE) | 2021-01-13 | — | — | EP | disclosed |
| CN-107635992-B | Tricyclic heterocyclic compounds useful as TNF inhibitors | 百时美施贵宝公司 | 2020-05-22 | — | — | CN | disclosed |
| EP-3271361-B1 | TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF | BRISTOL MYERS SQUIBB CO (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3271361-B1 | TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF | BRISTOL MYERS SQUIBB CO (US) | 2020-04-22 | — | — | EP | disclosed |
| US-20190350239-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2019-11-21 | — | — | US | disclosed |
| WO-1991010656-A1 | THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-07-25 | — | — | WO | disclosed |
| EP-0415948-A1 | PROCESS FOR PREPARING A SUBSTITUTED OR AN UNSUBSTITUTED 4(5)-($g(v)-AMINOALKYL)IMIDAZOLE | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989010360-A1 | PROCESS FOR PREPARING A SUBSTITUTED OR AN UNSUBSTITUTED 4(5)-(omega-AMINOALKYL)IMIDAZOLE | CEDONA PHARMACEUTICALS B.V. (NL) | 1989-11-02 | — | — | WO | disclosed |
| WO-1989005643-A1 | HETEROCYCLIC-SUBSTITUTED QUINOLINE-CARBOXYLIC ACIDS | PFIZER INC. (US) | 1989-06-29 | — | — | WO | disclosed |
| EP-0321191-A2 | Heterocyclic-substituted quinoline-carboxylic acids | PFIZER INC. (US) | 1989-06-21 | — | — | EP | disclosed |
| US-RE32868-E | Antihyperlipidemic compositions | RESEARCH CORPORATION (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0076035-B1 | PYRAZOLO(3,4-B)PYRIDINE DERIVATIVES | ICI AMERICAS INC. (US) | 1985-12-11 | — | — | EP | disclosed |
| US-4395417-A | Antihyperlipidemic compositions | RESEARCH CORPORATION (US) | 1983-07-26 | — | — | US | disclosed |
| EP-0076035-A1 | Pyrazolo(3,4-b)pyridine derivatives | ICI AMERICAS INC. (US) | 1983-04-06 | — | — | EP | disclosed |
| US-4364948-A | Pyrazolo[3,4-b]pyridine compounds | ICI AMERICAS INC. (US) | 1982-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11044931-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | TRPM8, TRPM7, TRPM2 | KMT2A 1629/4885PKM 2714/4885ALDH1A1 3977/4885 |
| US-20210338673-A1 | MNK INHIBITORS AND METHODS RELATED THERETO | TNNI3K, NIM1K, NEK9 | KMT2A 767/4885PKM 383/4885ALDH1A1 4285/4885 |
| US-20190350239-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | TRPM8, TRPM7, TRPM2 | KMT2A 1629/4885PKM 2714/4885ALDH1A1 3977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.