Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 6/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | PDE4A | P27815 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27552741 | 1.00 | PDE3A (0.60) | PDE3APDE3BHPGDKDM4EPDE4A | |
| SCHEMBL11259651 | 0.78 | PDE3A (0.61) | PDE3APDE3BHPGDKDM4EPDE4A | |
| SCHEMBL11259649 | 0.78 | PDE3A (0.61) | PDE3APDE3BHPGDKDM4EPDE4A | |
| SCHEMBL13346532 | 0.77 | PDE3B (0.38) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9309054 | 0.75 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL36947 | 0.75 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9301167 | 0.75 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9247989 | 0.75 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL28184205 | 0.74 | PDE3A (0.97) | PDE3APDE3BHPGDKDM4EPDE4A | |
| SCHEMBL11226409 | 0.73 | PDE3A (0.70) | PDE3APDE3BHPGDKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130597-A1 | DNA-PKCS MODULATES ENERGY REGULATION AND BRAIN FUNCTION | THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPT OF HEALTH AND HUMAN SERVICE (US) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130597-A1 | DNA-PKCS MODULATES ENERGY REGULATION AND BRAIN FUNCTION | PRKAB1, PRKAG1, PRKAB2 | PDE3A 2286/4885PDE3B 2479/4885HPGD 2290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.