Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 7/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.52 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375346 | 0.86 | MPO (0.72) | MPOHTR1AOPRM1OPRK1OPRL1 | |
| SCHEMBL13375737 | 0.84 | MPO (0.69) | MPOHTR1AOPRM1OPRK1OPRL1 | |
| SCHEMBL5170221 | 0.82 | MPO (0.77) | MPOHTR1ADRD2DRD4DRD3 | |
| SCHEMBL13499605 | 0.81 | MPO (1.00) | MPOHTR1ASLC6A4DRD2DRD4 | |
| SCHEMBL9635445 | 0.79 | MPO (0.73) | MPOHTR1ASLC6A4DRD2DRD4 | |
| SCHEMBL13374368 | 0.78 | KDM4E (0.60) | HTR2A | |
| SCHEMBL13374349 | 0.76 | ACHE (0.48) | DRD2DRD4 | |
| SCHEMBL6695064 | 0.72 | DRD2 (0.67) | MPOHTR1ASLC6A4DRD2DRD4 | |
| SCHEMBL5198405 | 0.72 | DRD2 (0.71) | MPOHTR1ASLC6A4DRD2DRD4 | |
| SCHEMBL13499597 | 0.72 | SLC6A4 (0.69) | MPOHTR1ASLC6A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288381-B2 | N-9 substituted purine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-10-16 | — | — | US | disclosed |