Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 8/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170221 | 0.88 | MPO (0.77) | MPOHTR1AGPR84DRD2DRD4 | |
| SCHEMBL13499605 | 0.84 | MPO (1.00) | MPOSLC6A4HTR1AGPR84DRD2 | |
| SCHEMBL9047205 | 0.84 | HTR1A (0.85) | MPOSLC6A4HTR1A | |
| SCHEMBL22584707 | 0.83 | GPR84 (0.58) | MPOSLC6A4GPR84DRD2DRD4 | |
| SCHEMBL739944 | 0.83 | HTR1A (0.79) | MPOSLC6A4HTR1A | |
| SCHEMBL14375346 | 0.82 | MPO (0.72) | MPOSLC6A4HTR1AGPR84DRD2 | |
| SCHEMBL13375737 | 0.80 | MPO (0.69) | MPOSLC6A4HTR1AGPR84DRD2 | |
| SCHEMBL17533456 | 0.80 | HTR1A (0.62) | HTR1AGPR84DRD2DRD4DRD3 | |
| SCHEMBL13374358 | 0.79 | MPO (0.67) | MPOSLC6A4HTR1AGPR84DRD2 | |
| SCHEMBL948663 | 0.79 | CYP2D6 (0.81) | SLC6A4HTR1ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114949-A | Treating disorders associated with 5HT uptake | RHONE-POULENC SANTE (FR) | 1992-05-19 | — | — | US | disclosed |