Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508014 | 0.75 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDRXFP1TSHR | |
| SCHEMBL29425214 | 0.75 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDRXFP1TSHR | |
| SCHEMBL16163017 | 0.73 | PDE7A (0.54) | ALDH1A1KDM4EHPGDRXFP1SMN1; SMN2 | |
| SCHEMBL9618264 | 0.71 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL29913568 | 0.70 | KDM4E (0.65) | ALDH1A1KDM4EHPGDRXFP1HTT | |
| SCHEMBL11981424 | 0.68 | KDM4E (0.67) | ALDH1A1KDM4EHPGDRXFP1HTT | |
| SCHEMBL22915226 | 0.67 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDRXFP1HTT | |
| SCHEMBL6427482 | 0.66 | SIGMAR1 (0.56) | — | |
| SCHEMBL11536434 | 0.64 | MAOA (0.47) | ALDH1A1KDM4EHPGDRXFP1SMN1; SMN2 | |
| SCHEMBL20960546 | 0.64 | KDM4E (0.64) | ALDH1A1KDM4EHPGDRXFP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063062-B2 | Alzheimer's disease, cognitive disorders, memory disorders, dementia, attention deficit disorder, traumatic brain injury, drug dependence, addiction; -chloro-N-{[3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazolyl]-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptylamino]methylene}benzene-sulfonamide | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-11-22 | — | — | US | disclosed |
| US-8063062-B2 | Alzheimer's disease, cognitive disorders, memory disorders, dementia, attention deficit disorder, traumatic brain injury, drug dependence, addiction; -chloro-N-{[3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazolyl]-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptylamino]methylene}benzene-sulfonamide | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-11-22 | — | — | US | disclosed |
| US-20080153867-A1 | COMPOUNDS WITH A COMBINATION OF CANNABINOID-CB1 ANTAGONISM AND ACETYLCHOLINESTERASE INHIBITION | SOLVAY PHARMACEUTICALS B.V. | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153867-A1 | COMPOUNDS WITH A COMBINATION OF CANNABINOID-CB1 ANTAGONISM AND ACETYLCHOLINESTERASE INHIBITION | ACHE, BACE1, BCHE | ALDH1A1 523/4885KDM4E 605/4885HPGD 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.