Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | CASP7 | P55210 | 1/20 | 0.65 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.58 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.57 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5496871 | 0.87 | TDP1 (0.65) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 | |
| SCHEMBL16657380 | 0.84 | ALDH1A1 (0.65) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 | |
| SCHEMBL13937044 | 0.84 | MAPT (0.63) | L3MBTL1TDP1ALDH1A1MAPK1HCAR3 | |
| SCHEMBL293916 | 0.82 | MAPT (0.72) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 | |
| SCHEMBL9943157 | 0.81 | L3MBTL1 (0.70) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 | |
| SCHEMBL1437915 | 0.81 | HCAR3 (0.68) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 | |
| SCHEMBL5159865 | 0.81 | L3MBTL1 (0.68) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 | |
| SCHEMBL4938163 | 0.81 | L3MBTL1 (0.68) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 | |
| SCHEMBL337857 | 0.81 | L3MBTL1 (0.68) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 | |
| SCHEMBL31026210 | 0.81 | L3MBTL1 (0.68) | L3MBTL1TDP1ALDH1A1MAPK1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063230-B1 | Tris(N-aryl benzimidazole)benzenes and their use in electronic devices | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-11-22 | — | — | US | disclosed |
| CN-101600701-A | Arylsulfonamide derivatives and methods of use thereof | WYETH CORP (US) | 2009-12-09 | — | — | CN | disclosed |
| US-20080161366-A1 | AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-07-03 | — | — | US | disclosed |
| EP-1789050-A1 | NOVEL QUINOXALINONE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Warner-Lambert Company LLC (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006016278-A1 | NOVEL QUINOXALINONE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY LLC (US) | 2006-02-16 | — | — | WO | disclosed |
| US-20060030566-A1 | Novel quinoxalinone norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | WARNER-LAMBERT COMPANY, LLC | 2006-02-09 | — | — | US | disclosed |
| EP-0558104-B1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO WELLCOME SPA (IT) | 1998-07-29 | — | — | EP | disclosed |
| EP-0623118-B1 | CARBAMATE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO WELLCOME SPA (IT) | 1998-05-13 | — | — | EP | disclosed |
| US-5637697-A | ANTAGONIST TO GASTRIN AND(OR) CHLOROCYSTOKININ | GLAXO SPA (IT) | 1997-06-10 | — | — | US | disclosed |
| US-5580895-A | GASTROINTESTINAL OR CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO SPA (IT) | 1996-12-03 | — | — | US | disclosed |
| US-5486514-A | GASTRIN, CHOLECYSTOKININ RECEPTOR ANTAGONISTS | GLAXO SPA (IT) | 1996-01-23 | — | — | US | disclosed |
| EP-0623118-A1 | CARBAMATE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO S.p.A. (IT) | 1994-11-09 | — | — | EP | disclosed |
| EP-0558104-A1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO S.p.A. (IT) | 1993-09-01 | — | — | EP | disclosed |
| WO-1993014074-A1 | 1,5-BENZODIAZEPINE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO SPA (IT) | 1993-07-22 | — | — | WO | disclosed |
| WO-1993014075-A1 | CARBAMATE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO SPA (IT) | 1993-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030566-A1 | Novel quinoxalinone norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | SLC6A2, SLC18A2, SLC6A3 | L3MBTL1 3304/4885TDP1 1150/4885ALDH1A1 612/4885 |
| US-20080161366-A1 | AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | SLC6A4, SLC6A2, SLC6A3 | L3MBTL1 4326/4885TDP1 367/4885ALDH1A1 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.