SCHEMBL1338461

SCHEMBL1338461

N#Cc1nc(Cl)cnc1Cl

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 2/20 0.38
POLB P06746 1/20 0.38
CSNK1A1 P48729 1/20 0.35
CLK4 Q9HAZ1 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
GAA P10253 1/20 0.34
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29380304 1.00 ALDH1A1 (0.38) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL11086636 0.84 ALDH1A1 (0.44) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL29420836 0.82 ALDH1A1 (0.42) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL376394 0.82 ALDH1A1 (0.42) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL23942769 0.78 ALDH1A1 (0.39) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL15257962 0.78 ALDH1A1 (0.36) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL24068622 0.78 ALDH1A1 (0.36) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL30605033 0.78 ALDH1A1 (0.36) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL28477092 0.78 ALDH1A1 (0.36) ALDH1A1KDM4EPOLBCSNK1A1CLK4
SCHEMBL12466516 0.78 ALDH1A1 (0.36) ALDH1A1KDM4EPOLBCSNK1A1CLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115707689-A Favipiravir impurity, preparation method and control method thereof 浙江华海药业股份有限公司 2023-02-21 CN claimed
CN-115598242-A HPLC (high performance liquid chromatography) detection method for contents of Favipiravir and key intermediates thereof 合肥利夫生物科技有限公司(CN) 2023-01-13 CN claimed
WO-2022009036-A1 SYNTHESIS OF FAVIPIRAVIR OPTIMUS DRUGS (P) LTD (IN) 2022-01-13 WO claimed
WO-2021240295-A1 PROCESS FOR PREPARATION OF FAVIPIRAVIR GLENMARK LIFE SCIENCES LIMITED (IN) 2021-12-02 WO claimed
CN-106866553-B Synthesis method of Favipiravir 中南大学 2020-02-04 CN claimed
CN-106866553-A A kind of synthetic method of Favipiravir 中南大学 2017-06-20 CN claimed
CN-106588786-A Preparation method of high purity favipiravir impurity 山东省药学科学院 2017-04-26 CN claimed
WO-2025039676-A1 PAN-KRAS PROTEIN TARGETED DEGRADER COMPOUND AND USE THEREOF 贝达药业股份有限公司 2025-02-27 WO disclosed
EP-4511114-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN Vertex Pharmaceuticals Incorporated (US) 2025-02-26 EP disclosed
EP-3519409-B1 BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING HIV INFECTION GILEAD SCIENCES INC (US) 2024-09-18 EP disclosed
CN-115636796-B Preparation method of fampicin 新发药业有限公司 2024-06-18 CN disclosed
WO-2024084447-A2 AZETIDINYL BENZOXAZOLE COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS DONG-A ST CO., LTD. (KR) 2024-04-25 WO disclosed
US-20240025924-A1 HETEROCYCLE SUBSTITUTED KETONE DERIVATIVE, AND COMPOSITION AND MEDICINAL USE THEREOF SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) 2024-01-25 US disclosed
EP-2192117-A1 ORGANIC AMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINECARBONITRILE AND METHOD FOR PRODUCING THE SAME Toyama Chemical Co., Ltd. (JP) 2010-06-02 EP disclosed
EP-1295890-B1 Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof TOYAMA CHEMICAL CO LTD (JP) 2005-04-27 EP disclosed
EP-1256588-B1 NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH TOYAMA CHEMICAL CO LTD (JP) 2005-02-02 EP disclosed
US-6800629-B2 VIRICIDES TOYAMA CHEMICAL CO., LTD. (JP) 2004-10-05 US disclosed
US-20030130213-A1 Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof TOYAMA CHEMICAL CO., LTD. (JP) 2003-07-10 US disclosed
EP-1295890-A1 Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof TOYAMA CHEMICAL CO., LTD. (JP) 2003-03-26 EP disclosed
EP-1256588-A1 NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH TOYAMA CHEMICAL CO., LTD. (JP) 2002-11-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240025924-A1 HETEROCYCLE SUBSTITUTED KETONE DERIVATIVE, AND COMPOSITION AND MEDICINAL USE THEREOF BCKDK, CYP11B2, HSD17B7 ALDH1A1 348/4885KDM4E 1880/4885POLB 2889/4885
US-20030130213-A1 Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof GTF3C5, EIF2AK2, GTF3C2 ALDH1A1 734/4885KDM4E 1860/4885POLB 2369/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.