Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22554365 | 0.80 | TAAR1 (0.42) | IDO1ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL22556234 | 0.79 | ALDH1A1 (0.35) | ALDH1A1MAPTHTT | |
| SCHEMBL28625785 | 0.78 | IDO1 (0.50) | IDO1MAPTRAB9ANPC1KMT2A | |
| SCHEMBL22556262 | 0.75 | HTR2A (0.42) | ALDH1A1MAPTSMN1; SMN2KMT2ATAAR1 | |
| SCHEMBL29237167 | 0.75 | NPC1 (0.50) | RAB9ANPC1PARP10KMT2AMEN1 | |
| SCHEMBL6391087 | 0.75 | IDO1 (0.47) | IDO1ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL28924 | 0.75 | IDO1 (0.55) | IDO1ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL22556216 | 0.74 | LPAR1 (0.36) | ALDH1A1SMN1; SMN2KMT2APOLBTAAR1 | |
| SCHEMBL689184 | 0.72 | NPC1 (0.48) | IDO1ALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL21089401 | 0.72 | IDO1 (0.62) | IDO1ALDH1A1MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163033-B2 | Nitrogen-containing heterocyclic compounds and methods of making the same | BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) | 2015-10-20 | — | — | US | disclosed |
| US-20140350246-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME | BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA (US) | 2014-11-27 | — | — | US | disclosed |
| US-20120271046-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME | BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120271046-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME | NISCH, HDHD5, DHPS | IDO1 460/4885ALDH1A1 582/4885MAPT 4697/4885 |
| US-20140350246-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME | NISCH, HDHD5, DHPS | IDO1 460/4885ALDH1A1 582/4885MAPT 4697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.