Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ADH1B | P00325 | 1/20 | 0.48 |
| ▸ | ADH1C | P00326 | 1/20 | 0.48 |
| ▸ | ADH1A | P07327 | 1/20 | 0.48 |
| ▸ | ADH7 | P40394 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6944557 | 0.98 | NPC1 (0.47) | NPC1RAB9AADH1BADH1CADH1A | |
| Bromide SCHEMBL38656295 | 0.98 | NPC1 (0.47) | NPC1RAB9AADH1BADH1CADH1A | |
| Ammonia Solution, Strong SCHEMBL28447660 | 0.98 | NPC1 (0.47) | NPC1RAB9AADH1BADH1CADH1A | |
| SCHEMBL21776500 | 0.98 | NPC1 (0.47) | NPC1RAB9AADH1BADH1CADH1A | |
| SCHEMBL27952705 | 0.98 | NPC1 (0.47) | NPC1RAB9AADH1BADH1CADH1A | |
| Methacrylic Acid SCHEMBL27804888 | 0.85 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1MAOB | |
| SCHEMBL22556262 | 0.81 | HTR2A (0.42) | ADH1BADH1CADH1AADH7TSHR | |
| SCHEMBL13477514 | 0.79 | LOXL2 (0.37) | KMT2AALDH1A1 | |
| SCHEMBL18661137 | 0.79 | TPSAB1 (0.41) | NPC1RAB9ACA1CA2CA9 | |
| SCHEMBL13477426 | 0.79 | KMT2A (0.51) | NPC1RAB9AIDO1AGXTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 488 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111960997-B | Method for synthesizing hydroxyalkyl substituted quinoline derivatives | 浙江工业大学 | 2021-10-12 | — | — | CN | claimed |
| CN-111960997-A | Method for synthesizing hydroxyalkyl substituted quinoline derivatives | 浙江工业大学 | 2020-11-20 | — | — | CN | claimed |
| US-9487494-B2 | Cyclic hydrocarbon compounds for the treatment of diseases | LEO PHARMA A/S (DK) | 2016-11-08 | — | — | US | claimed |
| CN-105753726-A | Preparation method for asymmetrical synthesis of pregabalin | 深圳市华先医药科技有限公司 | 2016-07-13 | — | — | CN | claimed |
| EP-1730152-B1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-05-02 | — | — | EP | claimed |
| EP-1975158-B9 | NOVEL PYRROLE DERIVATIVES WITH HISTONE DEACETYLASE INHIBITOR ACTIVITY | UNIV PAIS VASCO (ES) | 2012-02-29 | — | — | EP | claimed |
| US-20110319293-A1 | SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY | LIFESENSORS, INC. | 2011-12-29 | — | — | US | claimed |
| EP-1975158-B1 | NOVEL PYRROLE DERIVATIVES WITH HISTONE DEACETYLASE INHIBITOR ACTIVITY | UNIV PAIS VASCO (ES) | 2011-07-13 | — | — | EP | claimed |
| US-7879887-B2 | such as 2-(4-chloro-3-hydroxyphenylamino)-N-(6H-pyrazolo[4',3':3,4]benzo[1,2-d]thiazol-2-yl)-acetamide, having antitumor activity, particularly dual inhibitory activity on Aurora kinase and cyclin-dependent kinase (CDK), and are useful for cell proliferative diseases such as cancer | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-02-01 | — | — | US | claimed |
| US-20100317582-A1 | NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR THE TREATMENT OF DISEASES | LEO PHARMA A/S (DK) | 2010-12-16 | — | — | US | claimed |
| CN-1017800-B | TRICYCLIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 1992-08-12 | — | — | CN | claimed |
| EP-0497192-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-08-05 | — | — | EP | claimed |
| EP-0471609-A1 | Benzofuran Derivatives, Benzothiophenes, Indoles or Indolizines, Process for Production and Compositions containing them | SANOFI (FR) | 1992-02-19 | — | — | EP | claimed |
| EP-0173956-A1 | Sulfonyl-guanidinotriazine derivatives | BAYER AG (DE) | 1986-03-12 | — | — | EP | claimed |
| EP-0173317-A1 | Unsymmetrical sulfonyl guanidines | BAYER AG (DE) | 1986-03-05 | — | — | EP | claimed |
| EP-0173321-A1 | Sulfonyl-guanidinopyrimidine derivatives | BAYER AG (DE) | 1986-03-05 | — | — | EP | claimed |
| US-4436921-A | CARCINOSTATIC ACTIVITY | TOYAMA CHEMICAL CO., LTD. (JP) | 1984-03-13 | — | — | US | claimed |
| EP-0018063-B1 | PYRIDAZIN (2H)-3-ONES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN ANTIHYPERTENSIVE AGENTS | DIAMOND SHAMROCK CORPORATION (US) | 1983-02-23 | — | — | EP | claimed |
| US-4238490-A | Antihypertensive pyridazin(2H)-3-ones | DIAMOND SHAMROCK CORPORATION (US) | 1980-12-09 | — | — | US | claimed |
| EP-0018063-A1 | Pyridazin (2H)-3-ones, process for their preparation and their use in antihypertensive agents | DIAMOND SHAMROCK CORPORATION (US) | 1980-10-29 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317582-A1 | NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR THE TREATMENT OF DISEASES | ARNT, AHR, CYP27A1 | NPC1 190/4885RAB9A 4614/4885ADH1B 532/4885 |
| US-20110319293-A1 | SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY | SENP1, STUB1, SENP7 | NPC1 2546/4885RAB9A 3109/4885ADH1B 3939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.