Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.52 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.52 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | RRM1 | P23921 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 5/20 | 0.40 |
| ▸ | TERT | O14746 | 4/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13396360 | 0.88 | NOS1 (0.38) | GNAI3GNAO1GNAI1NOS1MMP2 | |
| SCHEMBL13396425 | 0.84 | GNAI3 (0.58) | GNAI3GNAO1GNAI1NOS1MMP2 | |
| SCHEMBL13396495 | 0.83 | GNAI3 (0.60) | GNAI3GNAO1GNAI1NOS1MMP2 | |
| SCHEMBL13396459 | 0.81 | GSR (0.36) | MMP2TLR2GSR | |
| SCHEMBL13397048 | 0.79 | NOD1 (0.42) | NOS1GSR | |
| SCHEMBL13396982 | 0.77 | DPP8 (0.39) | NOS1DPP7 | |
| SCHEMBL13396402 | 0.77 | GNAI3 (0.49) | GNAI3GNAO1GNAI1NOS1MMP2 | |
| SCHEMBL14153187 | 0.76 | GNAI3 (0.84) | GNAI3GNAO1GNAI1NOS1MMP2 | |
| SCHEMBL18851611 | 0.76 | GNAI3 (0.84) | GNAI3GNAO1GNAI1NOS1MMP2 | |
| SCHEMBL5497787 | 0.76 | GNAI3 (0.73) | GNAI3GNAO1GNAI1NOS1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266820-B2 | Nitric oxide donor compounds | NICOX SCIENCE IRELAND (IE) | 2016-02-23 | — | — | US | disclosed |
| US-20140288142-A1 | NITRIC OXIDE DONOR COMPOUNDS | NICOX SA (FR) | 2014-09-25 | — | — | US | disclosed |
| US-20100099729-A1 | NITRIC OXIDE DONOR COMPOUNDS | NICOX S.A. (FR) | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288142-A1 | NITRIC OXIDE DONOR COMPOUNDS | NOS3, NOS2, NOS1 | GNAI3 769/4885GNAO1 381/4885GNAI1 821/4885 |
| US-20100099729-A1 | NITRIC OXIDE DONOR COMPOUNDS | NOS3, NOS2, NOS1 | GNAI3 766/4885GNAO1 509/4885GNAI1 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.