Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 10/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | CASP6 | P55212 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | HTT | P42858 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | TDP2 | O95551 | 1/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401376 | 0.76 | MYC (1.00) | MEN1KMT2APOLBL3MBTL1HTT | |
| SCHEMBL3707610 | 0.75 | MEN1 (0.61) | MEN1KMT2ANPC1TLR9OPRK1 | |
| SCHEMBL14933689 | 0.74 | TNF (0.83) | MEN1KMT2ANPC1TLR9OPRK1 | |
| SCHEMBL14933690 | 0.74 | TNF (1.00) | MEN1KMT2ANPC1TLR9OPRK1 | |
| SCHEMBL16489004 | 0.74 | SLC25A1 (0.59) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL6141546 | 0.72 | PBRM1 (0.68) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL16489011 | 0.72 | MYC (0.60) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL13401763 | 0.71 | MAPT (0.65) | MEN1KMT2ANPC1TLR9OPRK1 | |
| SCHEMBL19334357 | 0.70 | MYC (0.80) | MEN1KMT2APOLBL3MBTL1HTT | |
| SCHEMBL5708771 | 0.70 | NPC1 (0.73) | MEN1KMT2ANPC1TLR9OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |
| US-8445537-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | STC.UNM (US) | 2013-05-21 | — | — | US | disclosed |
| US-20100099683-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099683-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | LIG1, LIG4, LIG3 | MEN1 2792/4885KMT2A 1608/4885NPC1 3302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.