SCHEMBL13408

SCHEMBL13408

c1cc2oncc2cn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30140932 1.00
SCHEMBL13549 0.81
Benzo[D]Isoxazole SCHEMBL29366929 0.70
Benzo[D]Isoxazole SCHEMBL1355530 0.70
Benzo[D]Isoxazole SCHEMBL8438 0.70
Benzo[D]Isoxazole SCHEMBL5778868 0.68 TDO2 (0.34)
Benzo[D]Isoxazole SCHEMBL28482344 0.68 TDO2 (0.39)
Benzo[D]Isoxazole SCHEMBL29184280 0.68 TDO2 (0.34)
Benzo[D]Isoxazole SCHEMBL21596877 0.68 TDO2 (0.34)
Benzo[D]Isoxazole SCHEMBL5158032 0.68 TDO2 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 505 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376079-B1 METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS VAN ANDEL RES INST (US) 2016-08-10 EP claimed
US-8173670-B2 Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids VAN ANDEL RESEARCH INSTITUTE (US) 2012-05-08 US claimed
EP-2376079-A1 METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS Van Andel Research Institute (US) 2011-10-19 EP claimed
US-20110251211-A9 METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-10-13 US claimed
WO-2010083218-A1 METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS VAN ANDEL RESEARCH INSTITUTE (US) 2010-07-22 WO claimed
US-20100179167-A1 METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS VAN ANDEL RESEARCH INSTITUTE 2010-07-15 US claimed
US-7122547-B1 Anthranilic acid amides and the use thereof as medicaments SCHERING AG (DE) 2006-10-17 US claimed
EP-1568368-A1 Pharmaceutical combination comprising a CDK inhibitor and a VEGF receptor inhibitor SCHERING AKTIENGESELLSCHAFT (DE) 2005-08-31 EP claimed
EP-1129074-A2 ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-05 EP claimed
WO-2000027819-A2 ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2000-05-18 WO claimed
US-20260124177-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR NOVITA PHARMACEUTICALS, INC. (US) 2026-05-07 US disclosed
EP-4735420-A1 ARYL INDOL-3-YL KETONE AND ARYL INDAZOL-3-YL KETONE INHIBITORS OF KIF18A Volastra Therapeutics, Inc. (US) 2026-05-06 EP disclosed
EP-4727548-A1 METHOD OF TREATING CANCER WITH INDOLINE INHIBITORS OF KIF18A Volastra Therapeutics, Inc. (US) 2026-04-22 EP disclosed
US-20260098018-A1 BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF CYTOKINETICS INC (US) 2026-04-09 US disclosed
US-12534471-B2 Pyrrolo[1, 2-c]imidazole derivatives as orexin type 2 receptor agonists and methods of use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-01-27 US disclosed
EP-1275301-A1 Trisubstituted heterocyclic compounds and their use as fungicides Bayer CropScience S.A. (FR) 2003-01-15 EP disclosed
EP-1129074-A2 ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-05 EP disclosed
WO-2000027819-A2 ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2000-05-18 WO disclosed
EP-0835242-A1 THIOAMIDES S-OXIDES FOR USE AS PESTICIDES Novartis AG (CH) 1998-04-15 EP disclosed
WO-1997000859-A1 THIOAMIDES S-OXIDES FOR USE AS PESTICIDES NOVARTIS AG (CH) 1997-01-09 WO disclosed