Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3519161 | 0.88 | ALDH1A1 (0.38) | MAPTL3MBTL1SMN1; SMN2MAOBALDH1A1 | |
| SCHEMBL13435221 | 0.85 | ALDH1A1 (0.39) | L3MBTL1CYP2C9CYP2C19MAOBALDH1A1 | |
| SCHEMBL13435223 | 0.83 | NPSR1 (0.41) | L3MBTL1SMN1; SMN2CYP2C9CYP2C19MAOB | |
| SCHEMBL3516982 | 0.81 | KDM4E (0.47) | MAPTL3MBTL1TDP1MAOBALDH1A1 | |
| SCHEMBL16274809 | 0.80 | CYP1A2 (0.42) | MAPTL3MBTL1SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL3514749 | 0.80 | KDM4E (0.47) | MAPTL3MBTL1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL3515900 | 0.78 | LMNA (0.44) | MAPTL3MBTL1SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL3516807 | 0.78 | KDM4E (0.45) | MAPTL3MBTL1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL3516270 | 0.75 | KDM4E (0.45) | L3MBTL1SMN1; SMN2CYP2C9ALDH1A1LMNA | |
| SCHEMBL3516194 | 0.75 | MEN1 (0.48) | MAPTL3MBTL1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | MAPT 3237/4885L3MBTL1 2155/4885SMN1; SMN2 1566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.