Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 4/20 | 0.42 |
| ▸ | NMT2 | O60551 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516039 | 0.80 | MAPK1 (0.39) | L3MBTL1ALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL16236493 | 0.79 | NPSR1 (0.43) | TSHRL3MBTL1MEN1KMT2AHSP90AA1 | |
| SCHEMBL3517908 | 0.75 | LMNA (0.41) | L3MBTL1MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL3515873 | 0.74 | POLB (0.39) | TSHRL3MBTL1MEN1KMT2AHSP90AA1 | |
| SCHEMBL3516526 | 0.74 | L3MBTL1 (0.55) | TSHRL3MBTL1MEN1KMT2AHSP90AA1 | |
| SCHEMBL1522806 | 0.74 | L3MBTL1 (0.55) | TSHRL3MBTL1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL16236403 | 0.73 | L3MBTL1 (0.54) | TSHRL3MBTL1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3519261 | 0.73 | L3MBTL1 (0.54) | TSHRL3MBTL1MEN1KMT2AHSP90AA1 | |
| SCHEMBL3517999 | 0.72 | MEN1 (0.38) | L3MBTL1MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL3517346 | 0.72 | KDM4E (0.43) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | TSHR 3624/4885L3MBTL1 2155/4885MEN1 3126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.