Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.43 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31703290 | 0.84 | ALDH1A1 (0.55) | POLBALDH1A1HTTSMN1; SMN2TRPM4 | |
| SCHEMBL31703491 | 0.83 | ALDH1A1 (0.42) | POLBALDH1A1HTTSMN1; SMN2TMPRSS4 | |
| SCHEMBL6341804 | 0.83 | ALDH1A1 (0.53) | POLBALDH1A1HTTSMN1; SMN2TRPM4 | |
| SCHEMBL22897687 | 0.80 | SMN1; SMN2 (0.49) | ALDH1A1HTTSMN1; SMN2TRPM4MAPK1 | |
| SCHEMBL29560180 | 0.80 | SMN1; SMN2 (0.49) | ALDH1A1HTTSMN1; SMN2TRPM4MAPK1 | |
| SCHEMBL14025078 | 0.79 | POLB (0.53) | POLBCXCR2CXCR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29914686 | 0.78 | POLB (0.53) | POLBALDH1A1HTTSMN1; SMN2MAPK1 | |
| SCHEMBL3755148 | 0.78 | POLB (0.53) | POLBALDH1A1HTTSMN1; SMN2MAPK1 | |
| SCHEMBL9031483 | 0.78 | ALDH1A1 (0.47) | CXCR2CXCR1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21409465 | 0.77 | MITF (0.51) | POLBALDH1A1HTTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |