Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13435579 | 0.68 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1GAAKDM4EPOLB | |
| SCHEMBL27808825 | 0.67 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1KDM4ERORCPOLB | |
| SCHEMBL13435818 | 0.67 | CNR2 (0.38) | ALDH1A1GAAKDM4ECACNA1BRORC | |
| SCHEMBL3485182 | 0.67 | NR1I2 (0.62) | SMN1; SMN2ALDH1A1GAANR1I2KDM4E | |
| SCHEMBL3486170 | 0.67 | NR1I2 (0.62) | ALDH1A1GAANR1I2KDM4ECACNA1B | |
| SCHEMBL28009386 | 0.64 | SHMT2 (0.39) | ALDH1A1GAAKDM4ENR1D1POLB | |
| SCHEMBL11389554 | 0.64 | NR1D1 (0.49) | ALDH1A1KDM4ENR1D1 | |
| SCHEMBL10228098 | 0.64 | CNR2 (0.51) | SMN1; SMN2KDM4ECACNA1BRORCCNR2 | |
| SCHEMBL8377833 | 0.63 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBMEN1MAPT | |
| SCHEMBL8377838 | 0.63 | ALDH1A1 (0.42) | ALDH1A1GAAKDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TRPV1, CACNA1S, TRPV2 | SMN1; SMN2 650/4885ALDH1A1 541/4885GAA 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.