Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB9 | P28065 | 12/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247428 | 0.91 | PSMB9 (0.34) | PSMB9PSMB8KDM4EALDH1A1GAA | |
| SCHEMBL12784133 | 0.86 | MEN1 (0.33) | — | |
| SCHEMBL8249221 | 0.84 | CTSB (0.41) | PSMB9PSMB8 | |
| SCHEMBL15509451 | 0.84 | CTSB (0.41) | PSMB9PSMB8 | |
| SCHEMBL7914476 | 0.84 | CTSB (0.41) | PSMB9PSMB8 | |
| SCHEMBL15509452 | 0.84 | CTSB (0.41) | PSMB9PSMB8 | |
| SCHEMBL15509453 | 0.84 | CTSB (0.41) | PSMB9PSMB8 | |
| SCHEMBL16747642 | 0.83 | PSMB9 (0.32) | PSMB9PSMB8ALOX15HSD17B10 | |
| SCHEMBL8246800 | 0.83 | CTSB (0.34) | PSMB9PSMB8KDM4EALDH1A1MAPT | |
| SCHEMBL18156074 | 0.82 | ALOX15 (0.31) | ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177523-A1 | Novel macrocyclic inhibitors of hepatitis c virus replication | Intermune, Inc. (US) | 2010-04-21 | — | — | EP | disclosed |