Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 2/20 | 0.46 |
| ▸ | CD74 | P04233 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14038766 | 0.83 | KMT2A (0.56) | HPGDKMT2AMEN1CYP3A4SMN1; SMN2 | |
| SCHEMBL4392970 | 0.80 | LMNA (0.60) | HPGDKMT2AMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL7835720 | 0.79 | KMT2A (0.69) | HPGDKMT2AMEN1CYP3A4SMN1; SMN2 | |
| SCHEMBL4490722 | 0.75 | KMT2A (0.64) | HPGDKMT2AMEN1CYP3A4SMN1; SMN2 | |
| SCHEMBL11730687 | 0.75 | HPGD (0.59) | HPGDKMT2AMEN1CYP3A4SMN1; SMN2 | |
| SCHEMBL23660840 | 0.75 | KMT2A (0.51) | HPGDKMT2AMEN1CYP3A4SMN1; SMN2 | |
| SCHEMBL4376107 | 0.75 | MAPK14 (0.57) | HPGDKMT2AMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL22925889 | 0.73 | ALDH1A1 (0.50) | HPGDCYP3A4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4481745 | 0.73 | ALDH1A1 (0.47) | HPGDKMT2AMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL1031237 | 0.72 | HPGD (0.73) | HPGDKMT2AMEN1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. | 2010-03-18 | — | — | US | disclosed |
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. | 2010-03-18 | — | — | US | disclosed |
| WO-2008127274-A2 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | NSUN3, TARBP1, TRMT1 | HPGD 1849/4885KMT2A 2284/4885MEN1 4179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.