Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769749 | 0.78 | TSHR (0.43) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL8622658 | 0.75 | EPHX2 (0.36) | ALDH1A1GLATSHRRIPK1CES2 | |
| SCHEMBL9537232 | 0.73 | TSHR (0.33) | ALDH1A1GLATSHRRIPK1 | |
| SCHEMBL2475462 | 0.72 | ALDH1A1 (0.44) | ALDH1A1GLATSHRMEN1KMT2A | |
| SCHEMBL1904633 | 0.72 | POLQ (0.50) | ALDH1A1GLATSHRMEN1KMT2A | |
| SCHEMBL1429977 | 0.71 | ALDH1A1 (0.44) | ALDH1A1GLATSHRMEN1KMT2A | |
| SCHEMBL2595067 | 0.70 | ALDH1A1 (0.42) | ALDH1A1GLATSHRMEN1KMT2A | |
| SCHEMBL545097 | 0.70 | TSHR (0.45) | ALDH1A1GLATSHRLMNA | |
| SCHEMBL2487489 | 0.69 | TSHR (0.36) | ALDH1A1GLATSHRMEN1KMT2A | |
| SCHEMBL7698910 | 0.69 | ALDH1A1 (0.41) | ALDH1A1GLATSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063221-B2 | Aminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-11-22 | — | — | US | disclosed |
| EP-2383271-A1 | Aminoquinolones as GSK-3 Inhibitors | Kyorin Pharmaceutical Co., Ltd. (JP) | 2011-11-02 | — | — | EP | disclosed |