Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLQ | O75417 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9084110 | 0.81 | TSHR (0.42) | TSHRALDH1A1CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL9302078 | 0.81 | ALDH1A1 (0.48) | TSHRALDH1A1CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL798178 | 0.76 | TSHR (0.49) | TSHRALDH1A1CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL2475462 | 0.73 | ALDH1A1 (0.44) | TSHRALDH1A1CYP3A4KMT2ATP53 | |
| SCHEMBL8622658 | 0.72 | EPHX2 (0.36) | TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL1904633 | 0.72 | POLQ (0.50) | TSHRALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1429977 | 0.71 | ALDH1A1 (0.44) | TSHRALDH1A1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL28807356 | 0.71 | TERT (0.47) | TSHRALDH1A1CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL2595067 | 0.71 | ALDH1A1 (0.42) | TSHRALDH1A1CYP3A4SMN1; SMN2KMT2A | |
| SCHEMBL545097 | 0.71 | TSHR (0.45) | TSHRALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221295-A1 | MONOCARBOXYLATE TRANSPORT MODULATORS AND USES THEREOF | Nirogyone Therapeutics, Inc. (US) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016081464-A1 | MONOCARBOXYLATE TRANSPORT MODULATORS AND USES THEREOF | NIROGYONE THERAPEUTICS, INC. (US) | 2016-05-26 | — | — | WO | disclosed |