Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13460932 | 0.93 | LMNA (0.44) | ROCK2ROCK1LMNAMAPTTHRB | |
| SCHEMBL13460776 | 0.90 | PPARD (0.47) | MAPTTHRBRECQLPPARAPPARD | |
| SCHEMBL13460937 | 0.89 | TAS1R3 (0.41) | ROCK2ROCK1LMNAMAPTTHRB | |
| SCHEMBL13460744 | 0.88 | PPARD (0.44) | ROCK2ROCK1PPARATAS1R3TAS1R1 | |
| SCHEMBL3416709 | 0.87 | MRGPRX4 (0.48) | ROCK2ROCK1LMNAMAPTTHRB | |
| SCHEMBL13460875 | 0.86 | ROCK2 (0.45) | ROCK2ROCK1LMNATHRBTSHR | |
| SCHEMBL13461048 | 0.85 | RECQL (0.42) | ROCK2ROCK1LMNAMAPTTHRB | |
| SCHEMBL13461041 | 0.85 | LMNA (0.46) | ROCK2ROCK1LMNATHRBTSHR | |
| SCHEMBL13460741 | 0.84 | LMNA (0.45) | ROCK2ROCK1LMNATHRBTSHR | |
| SCHEMBL13460746 | 0.84 | LMNA (0.43) | ROCK2ROCK1LMNAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |