Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ME2 | P23368 | 1/20 | 0.39 |
| ▸ | ME1 | P48163 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2312607 | 0.77 | GAA (0.61) | GAAKMT2ALMNAMAPTKDM4E | |
| SCHEMBL2312088 | 0.77 | GAA (0.61) | GAAKMT2ALMNAMAPTKDM4E | |
| SCHEMBL13465769 | 0.69 | MAPT (0.51) | GAAKMT2ALMNAMAPTKDM4E | |
| SCHEMBL12293861 | 0.68 | SLC6A7 (0.52) | GAAKMT2ALMNAMAPTKDM4E | |
| SCHEMBL12061585 | 0.68 | KDM5A (0.47) | GAALMNAKDM4EKDM1AHDAC1 | |
| SCHEMBL3801230 | 0.66 | ME2 (0.61) | GAAKMT2ALMNAMAPTKDM4E | |
| SCHEMBL23008892 | 0.66 | SMN1; SMN2 (0.75) | GAAKMT2ALMNAMAPTHTT | |
| SCHEMBL10357586 | 0.66 | HPGD (0.51) | KMT2AMAPTKDM4EHTTALDH1A1 | |
| SCHEMBL23244257 | 0.65 | ALDH1A1 (0.55) | GAAKMT2ALMNAMAPTKDM4E | |
| SCHEMBL1543956 | 0.65 | KDM4E (0.55) | LMNAMAPTKDM4EHDAC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028776-A1 | PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-18 | — | — | WO | disclosed |