Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.77 |
| ▸ | DRD2 | P14416 | 5/20 | 0.77 |
| ▸ | DRD1 | P21728 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.74 |
| ▸ | PKM | P14618 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.74 |
| ▸ | THPO | P40225 | 2/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.74 |
| ▸ | RGS12 | O14924 | 1/20 | 0.74 |
| ▸ | MTOR | P42345 | 1/20 | 0.74 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | GMNN | O75496 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346087 | 1.00 | HTR1A (0.77) | HTR1ADRD2DRD1ALDH1A1MAPT | |
| SCHEMBL12877888 | 0.89 | DRD2 (0.75) | HTR1ADRD2DRD1ALDH1A1MAPT | |
| SCHEMBL1346072 | 0.88 | DRD2 (0.75) | HTR1ADRD2DRD1ALDH1A1MAPT | |
| SCHEMBL1347782 | 0.88 | DRD2 (0.75) | HTR1ADRD2DRD1ALDH1A1MAPT | |
| SCHEMBL1348125 | 0.87 | HTR1A (1.00) | HTR1ADRD2DRD1ALDH1A1MAPT | |
| SCHEMBL1348123 | 0.87 | HTR1A (1.00) | HTR1ADRD2DRD1ALDH1A1MAPT | |
| SCHEMBL1204517 | 0.86 | DRD1 (1.00) | HTR1ADRD2DRD1DRD3HTR2A | |
| SCHEMBL1204032 | 0.86 | DRD1 (1.00) | HTR1ADRD2DRD1DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL9468991 | 0.86 | HTR1A (0.97) | HTR1ADRD2DRD1ALDH1A1MAPT | |
| SCHEMBL8344207 | 0.85 | DRD2 (1.00) | DRD2DRD1ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063060-B2 | R(−)-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100081651-A1 | R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-04-01 | — | — | US | disclosed |
| US-7648995-B2 | R(—)-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-01-19 | — | — | US | disclosed |
| US-20060040900-A1 | R(-)-11-hydroxyaporphine derivatives and uses thereof | MCLEAN HOSPITAL CORPORATION, THE | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040900-A1 | R(-)-11-hydroxyaporphine derivatives and uses thereof | SNCA, HTR5A, PARK7 | HTR1A 5/4885DRD2 23/4885DRD1 34/4885 |
| US-20100081651-A1 | R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | SNCA, HTR5A, HTR3A | HTR1A 5/4885DRD2 23/4885DRD1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.