Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342540 | 0.82 | KDM4E (0.52) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL221374 | 0.79 | MGAM (0.45) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL15426418 | 0.79 | ALOX5AP (0.39) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL15426421 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL983700 | 0.77 | MAPT (0.61) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL15426414 | 0.77 | LMNA (0.34) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL29657204 | 0.76 | MAPT (0.69) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL2906176 | 0.76 | MAPT (0.59) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL2485030 | 0.75 | S1PR1 (0.45) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL12342541 | 0.74 | S1PR1 (0.44) | SMN1; SMN2KDM4ENPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-B1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS INC (US) | 2012-10-17 | — | — | EP | disclosed |