Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13472149 | 0.92 | CSF1R (0.43) | CSF1RAXLEPHX2MCHR1SYK | |
| SCHEMBL3652871 | 0.88 | LTA4H (0.40) | CSF1RAXLEPHX2MCHR1SYK | |
| SCHEMBL13472142 | 0.84 | LTA4H (0.46) | SYKLTA4HHTR1AHTR7 | |
| SCHEMBL3650361 | 0.82 | CSF1R (0.41) | CSF1RAXLEPHX2MCHR1DRD2 | |
| SCHEMBL13472147 | 0.80 | SYK (0.40) | SYK | |
| SCHEMBL3642830 | 0.80 | CSF1R (0.45) | CSF1REPHX2DRD2LTA4HHTR2A | |
| SCHEMBL1735235 | 0.78 | LTA4H (0.52) | MCHR1SYKDRD2LTA4HFLT3 | |
| SCHEMBL27785763 | 0.78 | EGFR (0.41) | CSF1RAXLEPHX2MCHR1DRD2 | |
| SCHEMBL3650367 | 0.78 | EGFR (0.39) | AXL | |
| SCHEMBL17842417 | 0.77 | LTA4H (0.52) | EPHX2DRD2LTA4HHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293757-B2 | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |