Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13472146 | 0.92 | CSF1R (0.42) | CSF1RAXLMCHR1DRD2EPHX2 | |
| SCHEMBL3650361 | 0.90 | CSF1R (0.41) | CSF1RAXLMCHR1DRD2EPHX2 | |
| SCHEMBL3642830 | 0.88 | CSF1R (0.45) | CSF1RDRD2EPHX2HTR2AHTR2C | |
| SCHEMBL3652871 | 0.81 | LTA4H (0.40) | CSF1RAXLMCHR1DRD2EPHX2 | |
| SCHEMBL13472143 | 0.78 | LTA4H (0.51) | LMNAALDH1A1KCNH2HRH3SYK | |
| SCHEMBL27785763 | 0.78 | EGFR (0.41) | CSF1RAXLMCHR1DRD2EPHX2 | |
| SCHEMBL13472142 | 0.77 | LTA4H (0.46) | HRH3BTKSYK | |
| SCHEMBL13472151 | 0.75 | LMNA (0.52) | LMNAALDH1A1 | |
| SCHEMBL1735396 | 0.75 | KCNH2 (0.55) | LMNAALDH1A1KCNH2HRH3JAK3 | |
| SCHEMBL13472144 | 0.73 | ALDH1A1 (0.50) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293757-B2 | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |