Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13472151 | 0.89 | LMNA (0.52) | KMT2ALMNA | |
| SCHEMBL3654033 | 0.88 | EGFR (0.39) | SYKS1PR1BTKABL1 | |
| SCHEMBL13472146 | 0.80 | CSF1R (0.42) | SYK | |
| SCHEMBL13472142 | 0.80 | LTA4H (0.46) | SYKBTK | |
| SCHEMBL3644483 | 0.79 | LMNA (0.45) | KCNH2KMT2ALMNA | |
| SCHEMBL3652219 | 0.78 | EGFR (0.39) | SYKS1PR1BTKABL1 | |
| SCHEMBL12846723 | 0.78 | MELK (0.40) | SYKS1PR1BTK | |
| SCHEMBL1735359 | 0.77 | OPRM1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL1734487 | 0.76 | OPRM1 (0.45) | — | |
| SCHEMBL13472144 | 0.75 | ALDH1A1 (0.50) | KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293757-B2 | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |